Abstract
In this study, novel water-sol. corrole amino acid conjugates were synthesized and characterized. The coupling reaction of A2B- and A3-corroles with glycine Et ester and taurine under strong basic conditions proved to be successful and yielded di- and trifunctionalized corrole amino acid conjugates in good yields. The subsequent metalation of the corrole/amino acid conjugates broadens the scope for applications considerably. As examples, we herein show the catalytic activity of the Mn(III) A3-corrole towards O2 evolution. First we employed tert-Bu hydroperoxide (t-BuOOH) as oxidant to obtain the Mn(V)oxo species and tetra-Bu ammonium hydroxide (TBAH) as hydroxide donor agent. Furthermore, the binding properties of the non-metalated and the Mn(III) A3-corrole/amino sulfonic acid conjugates and transport of proteins were investigated and the conjugates exhibited binding to human serum albumin (HSA). Finally, a novel Ga(III) A3-corrole/amino sulfonic acid deriv. was synthesized and we briefly describe the photophys. properties of this compd.
| Original language | English |
|---|---|
| Pages (from-to) | 395-405 |
| Number of pages | 11 |
| Journal | Applied Organometallic Chemistry |
| Volume | 27 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2013 |
Fields of science
- 103 Physics, Astronomy
- 104003 Inorganic chemistry
- 104 Chemistry
- 107 Other Natural Sciences
- 301904 Cancer research
- 301305 Medical chemistry
JKU Focus areas
- Nano-, Bio- and Polymer-Systems: From Structure to Function
- Engineering and Natural Sciences (in general)