TY - GEN
T1 - Viscoelasticity and dielectric measurement of small sample volume for diagnostic platform of synovial fluid
AU - Reichel, Erwin
AU - Abdallah, Ali
AU - Feichtenschlager, Christian
AU - Kramer, Martin
AU - Moritz, Andreas
AU - Jakoby, Bernhard
PY - 2015/9
Y1 - 2015/9
N2 - The synovial fluid is found in joints of vertebrates and contains a high molecular weight polysaccharide (hyaluronan) acting as a modifier to ensure proper lubrication. Both, its concentration and molecular weight are subject to pathological alterations in certain diseases. Laboratory analysis of physical properties is difficult because of the limited amount of sample volume (usually below 100 μl). We present a sensor platform which requires volumes below 10 μl to measure the viscoelastic properties in the kilohertz range and the electrochemical impedance spectrum (EIS) from 102 to 10 6 Hz. Two electrodynamic acoustic shear wave transducers are used to measure both the single-sided viscoelastic shear impedance and the transmission of shear waves. The same elements are used as electrodes for measuring the EIS with a precision impedance analyser. The device is supposed to be used for clinical diagnosis and therapy tracking.
AB - The synovial fluid is found in joints of vertebrates and contains a high molecular weight polysaccharide (hyaluronan) acting as a modifier to ensure proper lubrication. Both, its concentration and molecular weight are subject to pathological alterations in certain diseases. Laboratory analysis of physical properties is difficult because of the limited amount of sample volume (usually below 100 μl). We present a sensor platform which requires volumes below 10 μl to measure the viscoelastic properties in the kilohertz range and the electrochemical impedance spectrum (EIS) from 102 to 10 6 Hz. Two electrodynamic acoustic shear wave transducers are used to measure both the single-sided viscoelastic shear impedance and the transmission of shear waves. The same elements are used as electrodes for measuring the EIS with a precision impedance analyser. The device is supposed to be used for clinical diagnosis and therapy tracking.
UR - http://www.scopus.com/inward/record.url?scp=84985000593&partnerID=8YFLogxK
U2 - 10.1016/j.proeng.2015.08.598
DO - 10.1016/j.proeng.2015.08.598
M3 - Conference proceedings
VL - 120
T3 - Procedia Engineering
SP - 171
EP - 174
BT - Procedia Engineering Eurosensors 2015
PB - Elsevier
ER -