Virus-induced senescence is a driver and therapeutic target in COVID-19

Soyoung Lee; Yong Yu; Jakob Trimpert; Fahad Benthani; Mario Mairhofer; Paulina Richter-Pechanska; Emanuel Wyler; D. Belenki; Sabine Kaltenbrunner; Maria Pammer; Lea Kausche; Theresa C. Firsching; Kristina Dietert; Michael Schotsaert; Carles Martinez-Romero; Gagandeep Singh; Severine Kunz; Daniela Niemeyer; Riad Ghanem; Helmut Salzer; Christian Paar; Michael Mülleder; Melissa Uccellini; Edward G. Michaelis; Amjad Khan; A. Lau; Martin Schönlein; Anna Habringer; Josef Tomasits; Julia M. Adler; Susanne Kimeswenger; Achim D. Gruber; Wolfram Hoetzenecker; Herta Steinkellner; Bettina Purfürst; Reinhard Motz; Francesco Di Pierro; Bernd Lamprecht; Nikolaus Osterrieder; Markus Landthaler; Christian Drosten; Adolfo Garcia-Sastre; Rupert Langer; Marcus Rasler; Roland Eils; Maurice Reimann; Dorothy N. Y. Fan; Clemens Schmitt

doi:10.1038/s41586-021-03995-1

Virus-induced senescence is a driver and therapeutic target in COVID-19

Soyoung Lee
, Yong Yu
, Jakob Trimpert
, Fahad Benthani
, Mario Mairhofer
, Paulina Richter-Pechanska
, Emanuel Wyler
, D. Belenki
, Sabine Kaltenbrunner
, Maria Pammer
, Lea Kausche
, Theresa C. Firsching
, Kristina Dietert
, Michael Schotsaert
, Carles Martinez-Romero
, Gagandeep Singh
, Severine Kunz
, Daniela Niemeyer
, Riad Ghanem
, Helmut Salzer

Christian Paar, Michael Mülleder, Melissa Uccellini, Edward G. Michaelis, Amjad Khan, A. Lau, Martin Schönlein, Anna Habringer, Josef Tomasits, Julia M. Adler, Susanne Kimeswenger, Achim D. Gruber, Wolfram Hoetzenecker, Herta Steinkellner, Bettina Purfürst, Reinhard Motz, Francesco Di Pierro, Bernd Lamprecht, Nikolaus Osterrieder, Markus Landthaler, Christian Drosten, Adolfo Garcia-Sastre, Rupert Langer, Marcus Rasler, Roland Eils, Maurice Reimann, Dorothy N. Y. Fan, Clemens Schmitt

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	283-289
Number of pages	7
Journal	Nature
Volume	599
Issue number	7884
DOIs	https://doi.org/10.1038/s41586-021-03995-1
Publication status	Published - 11 Nov 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Fields of science

302087 Venereology
302024 Haematology
302055 Oncology
301101 General pathology
301108 Molecular pathology
302011 Dermatology

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10.1038/s41586-021-03995-1

Cite this

Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T. C., Dietert, K., Schotsaert, M., Martinez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., ... Schmitt, C. (2021). Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature, 599(7884), 283-289. https://doi.org/10.1038/s41586-021-03995-1

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title = "Virus-induced senescence is a driver and therapeutic target in COVID-19",

author = "Soyoung Lee and Yong Yu and Jakob Trimpert and Fahad Benthani and Mario Mairhofer and Paulina Richter-Pechanska and Emanuel Wyler and D. Belenki and Sabine Kaltenbrunner and Maria Pammer and Lea Kausche and Firsching, \{Theresa C.\} and Kristina Dietert and Michael Schotsaert and Carles Martinez-Romero and Gagandeep Singh and Severine Kunz and Daniela Niemeyer and Riad Ghanem and Helmut Salzer and Christian Paar and Michael M{\"u}lleder and Melissa Uccellini and Michaelis, \{Edward G.\} and Amjad Khan and A. Lau and Martin Sch{\"o}nlein and Anna Habringer and Josef Tomasits and Adler, \{Julia M.\} and Susanne Kimeswenger and Gruber, \{Achim D.\} and Wolfram Hoetzenecker and Herta Steinkellner and Bettina Purf{\"u}rst and Reinhard Motz and \{Di Pierro\}, Francesco and Bernd Lamprecht and Nikolaus Osterrieder and Markus Landthaler and Christian Drosten and Adolfo Garcia-Sastre and Rupert Langer and Marcus Rasler and Roland Eils and Maurice Reimann and Fan, \{Dorothy N. Y.\} and Clemens Schmitt",

year = "2021",

month = nov,

day = "11",

doi = "10.1038/s41586-021-03995-1",

language = "English",

volume = "599",

pages = "283--289",

journal = "Nature",

issn = "1476-4687",

publisher = "Macmillian Publishers Limited",

number = "7884",

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Lee, S , Yu, Y, Trimpert, J, Benthani, F, Mairhofer, M, Richter-Pechanska, P, Wyler, E, Belenki, D, Kaltenbrunner, S, Pammer, M, Kausche, L, Firsching, TC, Dietert, K, Schotsaert, M, Martinez-Romero, C, Singh, G, Kunz, S, Niemeyer, D, Ghanem, R, Salzer, H, Paar, C, Mülleder, M, Uccellini, M, Michaelis, EG, Khan, A, Lau, A, Schönlein, M, Habringer, A, Tomasits, J, Adler, JM, Kimeswenger, S, Gruber, AD, Hoetzenecker, W, Steinkellner, H, Purfürst, B, Motz, R, Di Pierro, F, Lamprecht, B, Osterrieder, N, Landthaler, M, Drosten, C, Garcia-Sastre, A, Langer, R, Rasler, M, Eils, R, Reimann, M, Fan, DNY & Schmitt, C 2021, 'Virus-induced senescence is a driver and therapeutic target in COVID-19', Nature, vol. 599, no. 7884, pp. 283-289. https://doi.org/10.1038/s41586-021-03995-1

TY - JOUR

T1 - Virus-induced senescence is a driver and therapeutic target in COVID-19

AU - Lee, Soyoung

AU - Yu, Yong

AU - Trimpert, Jakob

AU - Benthani, Fahad

AU - Mairhofer, Mario

AU - Richter-Pechanska, Paulina

AU - Wyler, Emanuel

AU - Belenki, D.

AU - Kaltenbrunner, Sabine

AU - Pammer, Maria

AU - Kausche, Lea

AU - Firsching, Theresa C.

AU - Dietert, Kristina

AU - Schotsaert, Michael

AU - Martinez-Romero, Carles

AU - Singh, Gagandeep

AU - Kunz, Severine

AU - Niemeyer, Daniela

AU - Ghanem, Riad

AU - Salzer, Helmut

AU - Paar, Christian

AU - Mülleder, Michael

AU - Uccellini, Melissa

AU - Michaelis, Edward G.

AU - Khan, Amjad

AU - Lau, A.

AU - Schönlein, Martin

AU - Habringer, Anna

AU - Tomasits, Josef

AU - Adler, Julia M.

AU - Kimeswenger, Susanne

AU - Gruber, Achim D.

AU - Hoetzenecker, Wolfram

AU - Steinkellner, Herta

AU - Purfürst, Bettina

AU - Motz, Reinhard

AU - Di Pierro, Francesco

AU - Lamprecht, Bernd

AU - Osterrieder, Nikolaus

AU - Landthaler, Markus

AU - Drosten, Christian

AU - Garcia-Sastre, Adolfo

AU - Langer, Rupert

AU - Rasler, Marcus

AU - Eils, Roland

AU - Reimann, Maurice

AU - Fan, Dorothy N. Y.

AU - Schmitt, Clemens

PY - 2021/11/11

Y1 - 2021/11/11

UR - https://pubmed.ncbi.nlm.nih.gov/34517409/

UR - https://www.scopus.com/pages/publications/85114771612

U2 - 10.1038/s41586-021-03995-1

DO - 10.1038/s41586-021-03995-1

M3 - Article

SN - 1476-4687

VL - 599

SP - 283

EP - 289

JO - Nature

JF - Nature

IS - 7884

ER -

Virus-induced senescence is a driver and therapeutic target in COVID-19

UN SDGs

Fields of science

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