Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1

Isabella Derler; Christoph Romanin

doi:10.1016/j.ceca.2023.102739

Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1

Department of Molecular and Membrane Biophysics

Research output: Contribution to journal › Article › peer-review

Abstract

Ca2+ release-activated Ca2+ (CRAC) channels are activated by the physical interaction of the Ca2+ sensor STIM1 in the endoplasmic reticulum and the Ca2+ channel, Orai1, in the plasma membrane. An Orai1 mutation (L138F) associated with tubular aggregate myopathy (TAM) exhibits constitutive activity independent of STIM1, which Yeung et al. [1] employed to provide novel insights into the Orai1 pore opening mechanism and fast Ca2+-dependent inactivation (FCDI).

Original language	English
Article number	102739
Pages (from-to)	102739
Number of pages	3
Journal	Cell Calcium
Volume	112
Issue number	112
DOIs	https://doi.org/10.1016/j.ceca.2023.102739
Publication status	Published - Jun 2023

Fields of science

103 Physics, Astronomy
106006 Biophysics

JKU Focus areas

Sustainable Development: Responsible Technologies and Management

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10.1016/j.ceca.2023.102739

Cite this

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title = "Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1",

abstract = "Ca2+ release-activated Ca2+ (CRAC) channels are activated by the physical interaction of the Ca2+ sensor STIM1 in the endoplasmic reticulum and the Ca2+ channel, Orai1, in the plasma membrane. An Orai1 mutation (L138F) associated with tubular aggregate myopathy (TAM) exhibits constitutive activity independent of STIM1, which Yeung et al. [1] employed to provide novel insights into the Orai1 pore opening mechanism and fast Ca2+-dependent inactivation (FCDI).",

author = "Isabella Derler and Christoph Romanin",

year = "2023",

month = jun,

doi = "10.1016/j.ceca.2023.102739",

language = "English",

volume = "112",

pages = "102739",

journal = "Cell Calcium",

issn = "0143-4160",

publisher = "Science Direct",

number = "112",

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TY - JOUR

T1 - Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1

AU - Derler, Isabella

AU - Romanin, Christoph

PY - 2023/6

Y1 - 2023/6

N2 - Ca2+ release-activated Ca2+ (CRAC) channels are activated by the physical interaction of the Ca2+ sensor STIM1 in the endoplasmic reticulum and the Ca2+ channel, Orai1, in the plasma membrane. An Orai1 mutation (L138F) associated with tubular aggregate myopathy (TAM) exhibits constitutive activity independent of STIM1, which Yeung et al. [1] employed to provide novel insights into the Orai1 pore opening mechanism and fast Ca2+-dependent inactivation (FCDI).

AB - Ca2+ release-activated Ca2+ (CRAC) channels are activated by the physical interaction of the Ca2+ sensor STIM1 in the endoplasmic reticulum and the Ca2+ channel, Orai1, in the plasma membrane. An Orai1 mutation (L138F) associated with tubular aggregate myopathy (TAM) exhibits constitutive activity independent of STIM1, which Yeung et al. [1] employed to provide novel insights into the Orai1 pore opening mechanism and fast Ca2+-dependent inactivation (FCDI).

UR - https://www.scopus.com/pages/publications/85152127351

U2 - 10.1016/j.ceca.2023.102739

DO - 10.1016/j.ceca.2023.102739

M3 - Article

SN - 0143-4160

VL - 112

SP - 102739

JO - Cell Calcium

JF - Cell Calcium

IS - 112

M1 - 102739

ER -

Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1

Abstract

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