The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease.

Etienne M. Schönbach; Rupert Strauss; Mohamed A. Ibrahim; Jessica L. Janes; Artur V Cideciyan; G. Birch David; Eberhart Zrenner; S. Ip Michael; Janet S. Sunness; Kong Xiangrong; Srinivas R. Sadda; Hendrik P.N. Scholl

doi:10.1016/j.ajo.2020.05.002

The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease.

Etienne M. Schönbach
, Rupert Strauss
, Mohamed A. Ibrahim
, Jessica L. Janes
, Artur V Cideciyan
, G. Birch David
, Eberhart Zrenner
, S. Ip Michael
, Janet S. Sunness
, Kong Xiangrong
, Srinivas R. Sadda
, Hendrik P.N. Scholl

Department of Ophthalmology and Optometry

Research output: Contribution to journal › Article › peer-review

Abstract

Sensitive, reproducible visual function biomarkers are necessary to evaluate the efficacy of emerging treatments for Stargardt disease type 1 in clinical trials. We previously demonstrated that fixation stability may serve as a secondary outcome parameter for visual function loss. However, the test duration and protocol have an unknown effect on the assessment of fixation stability. Here, we hypothesize that separate fixation testing with a single target is different from combined fixation testing using the same target with simultaneous perimetry testing.

Original language	English
Pages (from-to)	305-316
Number of pages	12
Journal	American Journal of Ophthalmology
Volume	217
DOIs	https://doi.org/10.1016/j.ajo.2020.05.002
Publication status	Published - Sept 2020

Fields of science

302007 Ophthalmology

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10.1016/j.ajo.2020.05.002

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Schönbach, E. M., Strauss, R., Ibrahim, M. A., Janes, J. L., Cideciyan, A. V., David, G. B., Zrenner, E., Michael, S. I., Sunness, J. S., Xiangrong, K., Sadda, S. R., & Scholl, H. P. N. (2020). The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease. American Journal of Ophthalmology, 217, 305-316. https://doi.org/10.1016/j.ajo.2020.05.002

@article{e5993246d0264ef99baec64c9c0576df,

title = "The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease.",

abstract = "Sensitive, reproducible visual function biomarkers are necessary to evaluate the efficacy of emerging treatments for Stargardt disease type 1 in clinical trials. We previously demonstrated that fixation stability may serve as a secondary outcome parameter for visual function loss. However, the test duration and protocol have an unknown effect on the assessment of fixation stability. Here, we hypothesize that separate fixation testing with a single target is different from combined fixation testing using the same target with simultaneous perimetry testing.",

author = "Sch{\"o}nbach, \{Etienne M.\} and Rupert Strauss and Ibrahim, \{Mohamed A.\} and Janes, \{Jessica L.\} and Cideciyan, \{Artur V\} and David, \{G. Birch\} and Eberhart Zrenner and Michael, \{S. Ip\} and Sunness, \{Janet S.\} and Kong Xiangrong and Sadda, \{Srinivas R.\} and Scholl, \{Hendrik P.N.\}",

year = "2020",

month = sep,

doi = "10.1016/j.ajo.2020.05.002",

language = "English",

volume = "217",

pages = "305--316",

journal = "American Journal of Ophthalmology",

issn = "1879-1891",

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T1 - The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease.

AU - Schönbach, Etienne M.

AU - Strauss, Rupert

AU - Ibrahim, Mohamed A.

AU - Janes, Jessica L.

AU - Cideciyan, Artur V

AU - David, G. Birch

AU - Zrenner, Eberhart

AU - Michael, S. Ip

AU - Sunness, Janet S.

AU - Xiangrong, Kong

AU - Sadda, Srinivas R.

AU - Scholl, Hendrik P.N.

PY - 2020/9

Y1 - 2020/9

N2 - Sensitive, reproducible visual function biomarkers are necessary to evaluate the efficacy of emerging treatments for Stargardt disease type 1 in clinical trials. We previously demonstrated that fixation stability may serve as a secondary outcome parameter for visual function loss. However, the test duration and protocol have an unknown effect on the assessment of fixation stability. Here, we hypothesize that separate fixation testing with a single target is different from combined fixation testing using the same target with simultaneous perimetry testing.

AB - Sensitive, reproducible visual function biomarkers are necessary to evaluate the efficacy of emerging treatments for Stargardt disease type 1 in clinical trials. We previously demonstrated that fixation stability may serve as a secondary outcome parameter for visual function loss. However, the test duration and protocol have an unknown effect on the assessment of fixation stability. Here, we hypothesize that separate fixation testing with a single target is different from combined fixation testing using the same target with simultaneous perimetry testing.

UR - https://www.scopus.com/pages/publications/85087693205

U2 - 10.1016/j.ajo.2020.05.002

DO - 10.1016/j.ajo.2020.05.002

M3 - Article

SN - 1879-1891

VL - 217

SP - 305

EP - 316

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

ER -

The Effect of Attention on Fixation Stability During Dynamic Fixation Testing in Stargardt Disease.

Abstract

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