The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Johanna Klughammer; Barbara Kiesel; Thomas Roetzer; Nikolaus Fortelny; Amelie Nemc; Karl-Heinz Nenning; Julia Furtner; Nathan C. Sheffield; Paul Datlinger; Nadine Peter; Martha Nowosielski; Marco Augustin; Mario Mischkulnig; Thomas Ströbel; Donat Alpar; Bekir Ergüner; Martin Senekowitsch; Patrizia Moser; Christian F. Freyschlag; Johannes Kerschbaumer; Claudius Thomé; Astrid E. Grams; Günther Stockhammer; Melitta Kitzwögerer; Stefan Oberndorfer; Franz Marhold; Serge Weis; Johannes Trenkler; Johanna Buchroithner; Josef Pichler; Johannes Haybaeck; Stefanie Krassnig; Kariem Mahdy  Ali; Gord  von Campe; Franz Payer; Camillo Sherif; Julius Preiser; Thomas Hauser; Peter A. Winkler; Waltraud Kleindienst; Franz Würtz; Tanisa Brandner-Kokalj; Martin Stultschnig; Stefan Schweiger; Karin Dieckmann; Matthias Preusser; Georg Langs; Bernhard Baumann; Engelbert Knosp; Georg Widhalm; Christine Marosi; Johannes A. Hainfellner; Adelheid Woehrer; Christoph Bock

doi:10.1038/s41591-018-0156-x

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Johanna Klughammer
, Barbara Kiesel
, Thomas Roetzer
, Nikolaus Fortelny
, Amelie Nemc
, Karl-Heinz Nenning
, Julia Furtner
, Nathan C. Sheffield
, Paul Datlinger
, Nadine Peter
, Martha Nowosielski
, Marco Augustin
, Mario Mischkulnig
, Thomas Ströbel
, Donat Alpar
, Bekir Ergüner
, Martin Senekowitsch
, Patrizia Moser
, Christian F. Freyschlag
, Johannes Kerschbaumer

Claudius Thomé, Astrid E. Grams, Günther Stockhammer, Melitta Kitzwögerer, Stefan Oberndorfer, Franz Marhold, Serge Weis, Johannes Trenkler, Johanna Buchroithner, Josef Pichler, Johannes Haybaeck, Stefanie Krassnig, Kariem Mahdy Ali, Gord von Campe, Franz Payer, Camillo Sherif, Julius Preiser, Thomas Hauser, Peter A. Winkler, Waltraud Kleindienst, Franz Würtz, Tanisa Brandner-Kokalj, Martin Stultschnig, Stefan Schweiger, Karin Dieckmann, Matthias Preusser, Georg Langs, Bernhard Baumann, Engelbert Knosp, Georg Widhalm, Christine Marosi, Johannes A. Hainfellner, Adelheid Woehrer^*, Christoph Bock

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1611-1624
Number of pages	14
Journal	Nature Medicine
Volume	24
Issue number	10
DOIs	https://doi.org/10.1038/s41591-018-0156-x
Publication status	Published - Oct 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Fields of science

303 Health Sciences
304 Medical Biotechnology
305 Other Human Medicine, Health Sciences
301 Medical-Theoretical Sciences, Pharmacy
302 Clinical Medicine
301101 General pathology
301108 Molecular pathology
302051 Neurosurgery
303039 Radiological technology
302013 Medical diagnostics
302043 Magnetic resonance imaging (MRI)
302010 Computed tomography (CT)
302071 Radiology
302070 Radiodiagnostics

JKU Focus areas

Medical Sciences (in general)
Health System Research
Clinical Research on Aging

Access to Document

10.1038/s41591-018-0156-x

Cite this

Klughammer, J., Kiesel, B., Roetzer, T., Fortelny, N., Nemc, A., Nenning, K.-H., Furtner, J., Sheffield, N. C., Datlinger, P., Peter, N., Nowosielski, M., Augustin, M., Mischkulnig, M., Ströbel, T., Alpar, D., Ergüner, B., Senekowitsch, M., Moser, P., Freyschlag, C. F., ... Bock, C. (2018). The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space. Nature Medicine, 24(10), 1611-1624. https://doi.org/10.1038/s41591-018-0156-x

@article{f1599fb173534b3d80b2e552bec05c79,

title = "The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space",

author = "Johanna Klughammer and Barbara Kiesel and Thomas Roetzer and Nikolaus Fortelny and Amelie Nemc and Karl-Heinz Nenning and Julia Furtner and Sheffield, \{Nathan C.\} and Paul Datlinger and Nadine Peter and Martha Nowosielski and Marco Augustin and Mario Mischkulnig and Thomas Str{\"o}bel and Donat Alpar and Bekir Erg{\"u}ner and Martin Senekowitsch and Patrizia Moser and Freyschlag, \{Christian F.\} and Johannes Kerschbaumer and Claudius Thom{\'e} and Grams, \{Astrid E.\} and G{\"u}nther Stockhammer and Melitta Kitzw{\"o}gerer and Stefan Oberndorfer and Franz Marhold and Serge Weis and Johannes Trenkler and Johanna Buchroithner and Josef Pichler and Johannes Haybaeck and Stefanie Krassnig and Ali, \{Kariem Mahdy\} and \{von Campe\}, Gord and Franz Payer and Camillo Sherif and Julius Preiser and Thomas Hauser and Winkler, \{Peter A.\} and Waltraud Kleindienst and Franz W{\"u}rtz and Tanisa Brandner-Kokalj and Martin Stultschnig and Stefan Schweiger and Karin Dieckmann and Matthias Preusser and Georg Langs and Bernhard Baumann and Engelbert Knosp and Georg Widhalm and Christine Marosi and Hainfellner, \{Johannes A.\} and Adelheid Woehrer and Christoph Bock",

year = "2018",

month = oct,

doi = "10.1038/s41591-018-0156-x",

language = "English",

volume = "24",

pages = "1611--1624",

journal = "Nature Medicine",

issn = "1546-170X",

number = "10",

}

Klughammer, J, Kiesel, B, Roetzer, T, Fortelny, N, Nemc, A, Nenning, K-H, Furtner, J, Sheffield, NC, Datlinger, P, Peter, N, Nowosielski, M, Augustin, M, Mischkulnig, M, Ströbel, T, Alpar, D, Ergüner, B, Senekowitsch, M, Moser, P, Freyschlag, CF, Kerschbaumer, J, Thomé, C, Grams, AE, Stockhammer, G, Kitzwögerer, M, Oberndorfer, S, Marhold, F, Weis, S, Trenkler, J, Buchroithner, J, Pichler, J, Haybaeck, J, Krassnig, S, Ali, KM, von Campe, G, Payer, F, Sherif, C, Preiser, J, Hauser, T, Winkler, PA, Kleindienst, W, Würtz, F, Brandner-Kokalj, T, Stultschnig, M, Schweiger, S, Dieckmann, K, Preusser, M, Langs, G, Baumann, B, Knosp, E, Widhalm, G, Marosi, C, Hainfellner, JA, Woehrer, A & Bock, C 2018, 'The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space', Nature Medicine, vol. 24, no. 10, pp. 1611-1624. https://doi.org/10.1038/s41591-018-0156-x

TY - JOUR

T1 - The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

AU - Klughammer, Johanna

AU - Kiesel, Barbara

AU - Roetzer, Thomas

AU - Fortelny, Nikolaus

AU - Nemc, Amelie

AU - Nenning, Karl-Heinz

AU - Furtner, Julia

AU - Sheffield, Nathan C.

AU - Datlinger, Paul

AU - Peter, Nadine

AU - Nowosielski, Martha

AU - Augustin, Marco

AU - Mischkulnig, Mario

AU - Ströbel, Thomas

AU - Alpar, Donat

AU - Ergüner, Bekir

AU - Senekowitsch, Martin

AU - Moser, Patrizia

AU - Freyschlag, Christian F.

AU - Kerschbaumer, Johannes

AU - Thomé, Claudius

AU - Grams, Astrid E.

AU - Stockhammer, Günther

AU - Kitzwögerer, Melitta

AU - Oberndorfer, Stefan

AU - Marhold, Franz

AU - Weis, Serge

AU - Trenkler, Johannes

AU - Buchroithner, Johanna

AU - Pichler, Josef

AU - Haybaeck, Johannes

AU - Krassnig, Stefanie

AU - Ali, Kariem Mahdy

AU - von Campe, Gord

AU - Payer, Franz

AU - Sherif, Camillo

AU - Preiser, Julius

AU - Hauser, Thomas

AU - Winkler, Peter A.

AU - Kleindienst, Waltraud

AU - Würtz, Franz

AU - Brandner-Kokalj, Tanisa

AU - Stultschnig, Martin

AU - Schweiger, Stefan

AU - Dieckmann, Karin

AU - Preusser, Matthias

AU - Langs, Georg

AU - Baumann, Bernhard

AU - Knosp, Engelbert

AU - Widhalm, Georg

AU - Marosi, Christine

AU - Hainfellner, Johannes A.

AU - Woehrer, Adelheid

AU - Bock, Christoph

PY - 2018/10

Y1 - 2018/10

UR - https://www.ncbi.nlm.nih.gov/pubmed/30150718

UR - https://www.scopus.com/pages/publications/85053049192

U2 - 10.1038/s41591-018-0156-x

DO - 10.1038/s41591-018-0156-x

M3 - Article

C2 - 30150718

SN - 1546-170X

VL - 24

SP - 1611

EP - 1624

JO - Nature Medicine

JF - Nature Medicine

IS - 10

ER -

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

UN SDGs

Fields of science

JKU Focus areas

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Cite this