TY - JOUR
T1 - The 10,000 Eyes Study: Analysis of Keratometry, Abulafia-Koch regression transformation, and Biometric Eye Parameters Obtained With Swept-Source Optical Coherence Tomography
AU - Wendelstein, Jascha
AU - Reifeltshammer, Sophia
AU - Cooke, David L
AU - Hirnschall, Nino
AU - Hoffmann, Peter C.
AU - Langenbucher, Achim
AU - Bolz, Matthias
AU - Riaz, Kamran M
PY - 2022/9
Y1 - 2022/9
N2 - Purpose: To analyze Abulafia-Koch regression (AKRT), anterior and posterior astigmatism (K and TK), and evaluate biometry data in a large population.
Design: Retrospective cross-sectional study.
Methods: This multicenter (2 tertiary care centers) study analyzed datasets acquired between 2017 and 2020. Axial length (AL), corneal front and back radii (including meridians for K and TK conversion), horizontal corneal diameter, anterior chamber depth, lens thickness, and central corneal thickness were measured using telecentric keratometry and swept-source optical coherence tomography-based biometry (IOLMaster 700; Carl Zeiss Meditec AG). Cooke-modified axial length (CMAL) and AKRT were calculated. Difference vectors between K and TK astigmatism and between AKRT and TK astigmatism were compared.
Results: A total of 10,300 eyes from 6388 patients were assessed. Difference vectors for K and TK were significantly smaller than for AKRT and TK. K measurement showed a configuration of 51.49% of with-the-rule astigmatism and 30.51% against-the-rule astigmatism, TK measurement showed a configuration of 41.60% of with-the-rule astigmatism and 40.21% against-the-rule astigmatism. Mean total astigmatism was -0.94 ± 0.74 dpt. Mean values for AL and CMAL were 23.70 ± 1.39 mm and 23.70 ± 1.34 mm, respectively. Anterior chamber depth, lens thickness, horizontal corneal diameter, AL, and age were all correlated with each other.
Conclusion: Astigmatism analysis showed less difference between K and TK than between AKRT and TK. There were significantly fewer eyes with with-the-rule astigmatism and more eyes with against-the-rule astigmatism configuration in TK-derived than in K-derived keratometry. The study provides data on gender and generational differences in biometry. Significant intersexual differences in AL and CMAL were observed, with CMAL providing lower standard deviation compared with AL.
AB - Purpose: To analyze Abulafia-Koch regression (AKRT), anterior and posterior astigmatism (K and TK), and evaluate biometry data in a large population.
Design: Retrospective cross-sectional study.
Methods: This multicenter (2 tertiary care centers) study analyzed datasets acquired between 2017 and 2020. Axial length (AL), corneal front and back radii (including meridians for K and TK conversion), horizontal corneal diameter, anterior chamber depth, lens thickness, and central corneal thickness were measured using telecentric keratometry and swept-source optical coherence tomography-based biometry (IOLMaster 700; Carl Zeiss Meditec AG). Cooke-modified axial length (CMAL) and AKRT were calculated. Difference vectors between K and TK astigmatism and between AKRT and TK astigmatism were compared.
Results: A total of 10,300 eyes from 6388 patients were assessed. Difference vectors for K and TK were significantly smaller than for AKRT and TK. K measurement showed a configuration of 51.49% of with-the-rule astigmatism and 30.51% against-the-rule astigmatism, TK measurement showed a configuration of 41.60% of with-the-rule astigmatism and 40.21% against-the-rule astigmatism. Mean total astigmatism was -0.94 ± 0.74 dpt. Mean values for AL and CMAL were 23.70 ± 1.39 mm and 23.70 ± 1.34 mm, respectively. Anterior chamber depth, lens thickness, horizontal corneal diameter, AL, and age were all correlated with each other.
Conclusion: Astigmatism analysis showed less difference between K and TK than between AKRT and TK. There were significantly fewer eyes with with-the-rule astigmatism and more eyes with against-the-rule astigmatism configuration in TK-derived than in K-derived keratometry. The study provides data on gender and generational differences in biometry. Significant intersexual differences in AL and CMAL were observed, with CMAL providing lower standard deviation compared with AL.
UR - https://www.scopus.com/pages/publications/85140485334
U2 - 10.1016/j.ajo.2022.08.024
DO - 10.1016/j.ajo.2022.08.024
M3 - Article
SN - 1879-1891
VL - 245
SP - 44
EP - 60
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -