TY - JOUR
T1 - Structured ICU resource management in a pandemic is associated with favorable outcome in critically ill COVID‑19 patients
AU - Klein, Sebastian J
AU - Bellmann, Romuald
AU - Dejaco, Hannes
AU - Eschertzhuber, Stephan
AU - Fries, Dietmar
AU - Furtwängler, Wilhelm
AU - Gasteiger, Lukas
AU - Hasibeder, Walter
AU - Helbok, Raimund
AU - Hochhold, Christoph
AU - Hofer, Stefanie
AU - Kirchmair, Lukas
AU - Krismer, Christoph
AU - Ladner, Eugen
AU - Lehner, Georg F
AU - Mathis, Simon
AU - Mayr, Andreas
AU - Mittermayr, Markus
AU - Peer, Andreas
AU - Preuß Hernández, Christian
AU - Reitter, Bruno
AU - Ströhle, Mathias
AU - Swoboda, Michael
AU - Thomé, Claudius
AU - Joannidis, Michael
PY - 2020/11
Y1 - 2020/11
N2 - INTRODUCTION: On February 25, 2020, the first 2 patients were tested positive for severe acute respiratory syndrome coronavirus‑2 (SARS-CoV-2) in Tyrol, Austria. Rapid measures were taken to ensure adequate intensive care unit (ICU) preparedness for a surge of critically ill coronavirus disease-2019 (COVID-19) patients.METHODS: This cohort study included all COVID-19 patients admitted to an ICU with confirmed or strongly suspected COVID-19 in the State of Tyrol, Austria. Patients were recorded in the Tyrolean COVID-19 intensive care registry. Date of final follow-up was July 17, 2020.RESULTS: A total of 106 critically ill patients with COVID-19 were admitted to 1 of 13 ICUs in Tyrol from March 9 to July 17, 2020. Median age was 64 years (interquartile range, IQR 54-74 years) and the majority of patients were male (76 patients, 71.7%). Median simplified acute physiology score III (SAPS III) was 56 points (IQR 49-64 points). The median duration from appearance of first symptoms to ICU admission was 8 days (IQR 5-11 days). Invasive mechanical ventilation was required in 72 patients (67.9%) and 6 patients (5.6%) required extracorporeal membrane oxygenation treatment. Renal replacement therapy was necessary in 21 patients (19.8%). Median ICU length of stay (LOS) was 18 days (IQR 5-31 days), median hospital LOS was 27 days (IQR 13-49 days). The ICU mortality was 21.7% (23 patients), hospital mortality was 22.6%. There was no significant difference in ICU mortality in patients receiving invasive mechanical ventilation and in those not receiving it (18.1% vs. 29.4%, p = 0.284). As of July 17th, 2020, two patients are still hospitalized, one in an ICU, one on a general ward.CONCLUSION: Critically ill COVID-19 patients in Tyrol showed high severity of disease often requiring complex treatment with increased lengths of ICU and hospital stay. Nevertheless, the mortality was found to be remarkably low, which may be attributed to our adaptive surge response providing sufficient ICU resources.
AB - INTRODUCTION: On February 25, 2020, the first 2 patients were tested positive for severe acute respiratory syndrome coronavirus‑2 (SARS-CoV-2) in Tyrol, Austria. Rapid measures were taken to ensure adequate intensive care unit (ICU) preparedness for a surge of critically ill coronavirus disease-2019 (COVID-19) patients.METHODS: This cohort study included all COVID-19 patients admitted to an ICU with confirmed or strongly suspected COVID-19 in the State of Tyrol, Austria. Patients were recorded in the Tyrolean COVID-19 intensive care registry. Date of final follow-up was July 17, 2020.RESULTS: A total of 106 critically ill patients with COVID-19 were admitted to 1 of 13 ICUs in Tyrol from March 9 to July 17, 2020. Median age was 64 years (interquartile range, IQR 54-74 years) and the majority of patients were male (76 patients, 71.7%). Median simplified acute physiology score III (SAPS III) was 56 points (IQR 49-64 points). The median duration from appearance of first symptoms to ICU admission was 8 days (IQR 5-11 days). Invasive mechanical ventilation was required in 72 patients (67.9%) and 6 patients (5.6%) required extracorporeal membrane oxygenation treatment. Renal replacement therapy was necessary in 21 patients (19.8%). Median ICU length of stay (LOS) was 18 days (IQR 5-31 days), median hospital LOS was 27 days (IQR 13-49 days). The ICU mortality was 21.7% (23 patients), hospital mortality was 22.6%. There was no significant difference in ICU mortality in patients receiving invasive mechanical ventilation and in those not receiving it (18.1% vs. 29.4%, p = 0.284). As of July 17th, 2020, two patients are still hospitalized, one in an ICU, one on a general ward.CONCLUSION: Critically ill COVID-19 patients in Tyrol showed high severity of disease often requiring complex treatment with increased lengths of ICU and hospital stay. Nevertheless, the mortality was found to be remarkably low, which may be attributed to our adaptive surge response providing sufficient ICU resources.
KW - Aged
KW - Austria
KW - Betacoronavirus
KW - COVID-19
KW - Cohort Studies
KW - Coronavirus Infections/therapy
KW - Critical Illness/therapy
KW - Female
KW - Humans
KW - Intensive Care Units
KW - Male
KW - Middle Aged
KW - Pandemics
KW - Pneumonia, Viral/therapy
KW - SARS-CoV-2
KW - Treatment Outcome
UR - https://www.scopus.com/pages/publications/85095846935
U2 - 10.1007/s00508-020-01764-0
DO - 10.1007/s00508-020-01764-0
M3 - Article
C2 - 33170333
SN - 1613-7671
VL - 132
SP - 653
EP - 663
JO - Wiener klinische Wochenschrift
JF - Wiener klinische Wochenschrift
IS - 21-22
ER -
