Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study

Christoph Schwartz; A Romagna; Harald Stefanits; G Zimmermann; B Ladisich; P Geiger; J Rechberger; Sophie Winkler; G Fastner; Eugen Trinka; Serge Weis; Sabine Spiegl-Kreinecker; J Steinbacher; M McCoy; T. Johannes; Andreas Gruber; B Rezai Jahromi; M Niemelä; M Niemela; PA Winkler; N Thon

doi:10.1016/j.wneu.2019.09.097

Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study

Christoph Schwartz, A Romagna, Harald Stefanits, G Zimmermann, B Ladisich, P Geiger, J Rechberger, Sophie Winkler, G Fastner, Eugen Trinka, Serge Weis, Sabine Spiegl-Kreinecker, J Steinbacher, M McCoy, T. Johannes, Andreas Gruber, B Rezai Jahromi, M Niemelä, M Niemela, PA WinklerN Thon

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. METHODS: We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. CONCLUSIONS: Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.

Original language	English
Number of pages	19
Journal	World Neurosurgery
DOIs	https://doi.org/10.1016/j.wneu.2019.09.097
Publication status	Published - 2019

Fields of science

302 Clinical Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.wneu.2019.09.097

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Schwartz, C., Romagna, A., Stefanits, H., Zimmermann, G., Ladisich, B., Geiger, P., Rechberger, J., Winkler, S., Fastner, G., Trinka, E., Weis, S., Spiegl-Kreinecker, S., Steinbacher, J., McCoy, M., Johannes, T., Gruber, A., Rezai Jahromi, B., Niemelä, M., Niemela, M., ... Thon, N. (2019). Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study. World Neurosurgery. https://doi.org/10.1016/j.wneu.2019.09.097

@article{2ac09aa7d71e4102818a6e09307ee50a,

title = "Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study",

abstract = "OBJECTIVE: To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. METHODS: We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. CONCLUSIONS: Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.",

author = "Christoph Schwartz and A Romagna and Harald Stefanits and G Zimmermann and B Ladisich and P Geiger and J Rechberger and Sophie Winkler and G Fastner and Eugen Trinka and Serge Weis and Sabine Spiegl-Kreinecker and J Steinbacher and M McCoy and T. Johannes and Andreas Gruber and {Rezai Jahromi}, B and M Niemel{\"a} and M Niemela and PA Winkler and N Thon",

year = "2019",

doi = "10.1016/j.wneu.2019.09.097",

language = "English",

journal = "World Neurosurgery",

issn = "1878-8769",

publisher = "ELSEVIER SCIENCE INC",

}

Schwartz, C, Romagna, A, Stefanits, H, Zimmermann, G, Ladisich, B, Geiger, P, Rechberger, J, Winkler, S, Fastner, G, Trinka, E, Weis, S, Spiegl-Kreinecker, S, Steinbacher, J, McCoy, M, Johannes, T, Gruber, A, Rezai Jahromi, B, Niemelä, M, Niemela, M, Winkler, PA & Thon, N 2019, 'Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study', World Neurosurgery. https://doi.org/10.1016/j.wneu.2019.09.097

TY - JOUR

T1 - Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study

AU - Schwartz, Christoph

AU - Romagna, A

AU - Stefanits, Harald

AU - Zimmermann, G

AU - Ladisich, B

AU - Geiger, P

AU - Rechberger, J

AU - Winkler, Sophie

AU - Fastner, G

AU - Trinka, Eugen

AU - Weis, Serge

AU - Spiegl-Kreinecker, Sabine

AU - Steinbacher, J

AU - McCoy, M

AU - Johannes, T.

AU - Gruber, Andreas

AU - Rezai Jahromi, B

AU - Niemelä, M

AU - Niemela, M

AU - Winkler, PA

AU - Thon, N

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. METHODS: We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. CONCLUSIONS: Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.

AB - OBJECTIVE: To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. METHODS: We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. CONCLUSIONS: Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.

UR - https://www.ncbi.nlm.nih.gov/pubmed/31561040

U2 - 10.1016/j.wneu.2019.09.097

DO - 10.1016/j.wneu.2019.09.097

M3 - Article

SN - 1878-8769

JO - World Neurosurgery

JF - World Neurosurgery

ER -

Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study

Abstract

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UN SDGs

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