Abstract
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
| Original language | English |
|---|---|
| Publisher | Springer Nature AG, Switzerland |
| Volume | 115 |
| ISBN (Print) | 978-3-030-64852-7 |
| Publication status | Published - 2021 |
Fields of science
- 104 Chemistry
- 104021 Structural chemistry
- 104026 Spectroscopy
- 104015 Organic chemistry
- 104017 Physical chemistry
- 106002 Biochemistry
- 106041 Structural biology
- 301305 Medical chemistry
- 302043 Magnetic resonance imaging (MRI)
JKU Focus areas
- Sustainable Development: Responsible Technologies and Management