Polyvinyl Butyral DMN-Conjugates for the Controlled Release of Singlet Oxygen in Medical and Antimicrobial Applications

Damir Posavec; Rainer Müller; Udo Bogner; Günther Bernhardt; Günther Knör

doi:10.12989/bme.2014.1.2.073

Polyvinyl Butyral DMN-Conjugates for the Controlled Release of Singlet Oxygen in Medical and Antimicrobial Applications

Damir Posavec, Rainer Müller, Udo Bogner, Günther Bernhardt, Günther Knör (Editor)

Institute of Inorganic Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Covalent attachment of 1,4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.

Original language	English
Pages (from-to)	63-68
Number of pages	6
Journal	Biomaterials and Biomechanics in Bioengineering
Volume	1
Issue number	2
DOIs	https://doi.org/10.12989/bme.2014.1.2.073
Publication status	Published - 2014

Fields of science

104 Chemistry
104011 Materials chemistry
104016 Photochemistry
106032 Photobiology
210005 Nanophotonics
104003 Inorganic chemistry
104015 Organic chemistry
107002 Bionics
301305 Medical chemistry
301904 Cancer research

JKU Focus areas

Nano-, Bio- and Polymer-Systems: From Structure to Function
Engineering and Natural Sciences (in general)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.12989/bme.2014.1.2.073

Cite this

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title = "Polyvinyl Butyral DMN-Conjugates for the Controlled Release of Singlet Oxygen in Medical and Antimicrobial Applications",

abstract = "Covalent attachment of 1,4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.",

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T1 - Polyvinyl Butyral DMN-Conjugates for the Controlled Release of Singlet Oxygen in Medical and Antimicrobial Applications

AU - Posavec, Damir

AU - Müller, Rainer

AU - Bogner, Udo

AU - Bernhardt, Günther

A2 - Knör, Günther

PY - 2014

Y1 - 2014

N2 - Covalent attachment of 1,4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.

AB - Covalent attachment of 1,4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.

U2 - 10.12989/bme.2014.1.2.073

DO - 10.12989/bme.2014.1.2.073

M3 - Article

SN - 2465-9959

VL - 1

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EP - 68

JO - Biomaterials and Biomechanics in Bioengineering

JF - Biomaterials and Biomechanics in Bioengineering

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