Abstract
Two synthetic analogues of brassinosteroids (DI31 and S7) exhibit good plant growth enhancer activity. However, their hydrophobicity and quick metabolism in plants have limited their application and benefits in agriculture. Our objective was to prepare novel brassinosteroid-modified polyethylene glycol (PEG) micelles to achieve controlled release with
extended stability while retaining agrochemical activity. Spectroscopic studies confirmed quantitative disubstitution of studied PEGs with the brassinosteroids, while elemental analysis assessed purity of the synthesized conjugates. Conjugates were also characterized by X-ray diffraction and thermal analysis. Dynamic and static light scattering showed stable and homogeneous approximately spherical micelles with average hydrodynamic diameters of 22−120 nm and almost neutral ζ potential. Spherical 30−140 nm micelles were observed by electron microscopy. Sustained in vitro releases at pH 5.5 were extended up to 96 h.Prepared PEG micelles showed good agrochemical activity in the radish seed bioassay and no cytotoxicity to the human microvascular endothelial cell line in the MTS test.
| Original language | English |
|---|---|
| Number of pages | 8 |
| Journal | Journal of Agricultural and Food Chemistry |
| DOIs | |
| Publication status | Published - Jan 2018 |
Fields of science
- 304007 Tissue engineering
- 204002 Chemical reaction engineering
- 210004 Nanomaterials
- 104 Chemistry
- 104002 Analytical chemistry
- 104011 Materials chemistry
- 104014 Surface chemistry
- 104016 Photochemistry
- 104018 Polymer chemistry
- 104008 Catalysis
- 104010 Macromolecular chemistry
- 104015 Organic chemistry
- 104019 Polymer sciences
- 106002 Biochemistry
- 107002 Bionics
- 301305 Medical chemistry
- 301207 Pharmaceutical chemistry
- 301904 Cancer research
- 302009 Chemotherapy
JKU Focus areas
- Nano-, Bio- and Polymer-Systems: From Structure to Function
- Engineering and Natural Sciences (in general)