New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide

Elham Kianfar; Christine Schäfer; Mohammad Reza Lornejad; Engelbert Portenkirchner; Günther Knör

doi:10.1016/j.ica.2015.05.035

New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide

Elham Kianfar, Christine Schäfer, Mohammad Reza Lornejad, Engelbert Portenkirchner, Günther Knör (Editor)

Institute of Inorganic Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported quantum yields are in a suitable range for inducing beneficial therapeutic effects as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.

Original language	English
Pages (from-to)	174-177
Number of pages	4
Journal	Inorganica Chimica Acta
Volume	435
DOIs	https://doi.org/10.1016/j.ica.2015.05.035
Publication status	Published - 13 Jul 2015

Fields of science

104 Chemistry
104016 Photochemistry
106032 Photobiology
104003 Inorganic chemistry
301305 Medical chemistry
301904 Cancer research

JKU Focus areas

Nano-, Bio- and Polymer-Systems: From Structure to Function
Engineering and Natural Sciences (in general)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ica.2015.05.035

Cite this

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title = "New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide",

abstract = "Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported quantum yields are in a suitable range for inducing beneficial therapeutic effects as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.",

author = "Elham Kianfar and Christine Sch{\"a}fer and Lornejad, \{Mohammad Reza\} and Engelbert Portenkirchner and G{\"u}nther Kn{\"o}r",

year = "2015",

month = jul,

day = "13",

doi = "10.1016/j.ica.2015.05.035",

language = "English",

volume = "435",

pages = "174--177",

journal = "Inorganica Chimica Acta",

issn = "1873-3255",

publisher = "Elsevier",

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T1 - New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide

AU - Kianfar, Elham

AU - Schäfer, Christine

AU - Lornejad, Mohammad Reza

AU - Portenkirchner, Engelbert

A2 - Knör, Günther

PY - 2015/7/13

Y1 - 2015/7/13

N2 - Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported quantum yields are in a suitable range for inducing beneficial therapeutic effects as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.

AB - Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported quantum yields are in a suitable range for inducing beneficial therapeutic effects as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.

UR - https://www.scopus.com/pages/publications/84936952452

U2 - 10.1016/j.ica.2015.05.035

DO - 10.1016/j.ica.2015.05.035

M3 - Article

SN - 1873-3255

VL - 435

SP - 174

EP - 177

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide

Abstract

Fields of science

JKU Focus areas

UN SDGs

Access to Document

Other files and links

Functional Light-Responsive Metal Carbonyl Systems

Cite this

New Photo-CORMs: Deeply-coloured Biocompatible Rhenium Complexes for the Controlled Release of Carbon Monoxide

Abstract

Fields of science

JKU Focus areas

UN SDGs

Access to Document

Other files and links

Projects

Functional Light-Responsive Metal Carbonyl Systems

Cite this