Nanomechanical binding mechanism of ligands drives agonistic activity

Hannah Seferovic; Patricia Sticht; Lisa Hain; Rong Zhu; Sebastian Diethör; Christian Wechselberger; Florian Weber; David Bernhard; Birgit Plochberger; Yoo Jin Oh; Javier Chaparro-Riggers; Peter Hinterdorfer

doi:10.1038/s41467-025-61929-1

Nanomechanical binding mechanism of ligands drives agonistic activity

Hannah Seferovic
, Patricia Sticht
, Lisa Hain
, Rong Zhu
, Sebastian Diethör
, Christian Wechselberger
, Florian Weber
, David Bernhard
, Birgit Plochberger
, Yoo Jin Oh
, Javier Chaparro-Riggers
, Peter Hinterdorfer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	6674
Journal	Nature Communications
Volume	16
Issue number	1
Early online date	19 Jul 2025
DOIs	https://doi.org/10.1038/s41467-025-61929-1
Publication status	Published - 19 Jul 2025

Fields of science

210006 Nanotechnology
106013 Genetics
304003 Genetic engineering
302 Clinical Medicine
106023 Molecular biology
104015 Organic chemistry
104014 Surface chemistry
103 Physics, Astronomy
106006 Biophysics
301902 Immunology
206003 Medical physics
206002 Electro-medical engineering
206001 Biomedical engineering
106002 Biochemistry
301109 Pathophysiology

JKU Focus areas

Sustainable Development: Responsible Technologies and Management

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41467-025-61929-1

Cite this

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title = "Nanomechanical binding mechanism of ligands drives agonistic activity",

author = "Hannah Seferovic and Patricia Sticht and Lisa Hain and Rong Zhu and Sebastian Dieth{\"o}r and Christian Wechselberger and Florian Weber and David Bernhard and Birgit Plochberger and Oh, \{Yoo Jin\} and Javier Chaparro-Riggers and Peter Hinterdorfer",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = jul,

day = "19",

doi = "10.1038/s41467-025-61929-1",

language = "English",

volume = "16",

journal = "Nature Communications",

issn = "2041-1723",

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TY - JOUR

T1 - Nanomechanical binding mechanism of ligands drives agonistic activity

AU - Seferovic, Hannah

AU - Sticht, Patricia

AU - Hain, Lisa

AU - Zhu, Rong

AU - Diethör, Sebastian

AU - Wechselberger, Christian

AU - Weber, Florian

AU - Bernhard, David

AU - Plochberger, Birgit

AU - Oh, Yoo Jin

AU - Chaparro-Riggers, Javier

AU - Hinterdorfer, Peter

PY - 2025/7/19

Y1 - 2025/7/19

UR - https://www.scopus.com/pages/publications/105011183392

U2 - 10.1038/s41467-025-61929-1

DO - 10.1038/s41467-025-61929-1

M3 - Article

C2 - 40683864

AN - SCOPUS:105011183392

SN - 2041-1723

VL - 16

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 6674

ER -

Nanomechanical binding mechanism of ligands drives agonistic activity

Fields of science

JKU Focus areas

UN SDGs

Access to Document

Other files and links

Cite this