TY - JOUR
T1 - Management of children and adolescents with gray zone lymphoma: A case series
AU - Perwein, Thomas
AU - Lackner, Herwig
AU - Ebetsberger-Dachs, Georg
AU - Beham-Schmid, Christine
AU - Zach, Klara
AU - Tamesberger, Melanie
AU - et al., null
PY - 2020/2
Y1 - 2020/2
N2 - Background: Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce.
Procedure: This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male-to-female ratio: 1:1; median age: 15.8 years).
Results: Two patients each had a classical Hodgkin lymphoma (cHL)-like and composite GZL subtype, and one patient each had a large B-cell non-Hodgkin lymphoma (LBCL)-like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL- and one patient a cHL-directed polychemotherapy ± radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high-dose chemotherapy with autologous stem cell rescue. The latter patient survived.
Conclusions: GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.
AB - Background: Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce.
Procedure: This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male-to-female ratio: 1:1; median age: 15.8 years).
Results: Two patients each had a classical Hodgkin lymphoma (cHL)-like and composite GZL subtype, and one patient each had a large B-cell non-Hodgkin lymphoma (LBCL)-like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL- and one patient a cHL-directed polychemotherapy ± radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high-dose chemotherapy with autologous stem cell rescue. The latter patient survived.
Conclusions: GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.
UR - https://pubmed.ncbi.nlm.nih.gov/32037692/
U2 - 10.1002/pbc.28206
DO - 10.1002/pbc.28206
M3 - Article
SN - 1545-5017
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 5
M1 - e28206
ER -
