Immune Cell Deformability in Depressive Disorders: Longitudinal Associations Between Depression, Glucocorticoids and Cell Deformability

Marlene Penz; Andreas Walther; Martin Kräter; Clemens Kirschbaum; Wei Gao; Magdalena Wekenborg; Nicole Rothe; Jochen Gluck; Lucas Daniel Wittwer; Julian Eder

doi:10.1101/2022.09.23.22280275

Immune Cell Deformability in Depressive Disorders: Longitudinal Associations Between Depression, Glucocorticoids and Cell Deformability

Marlene Penz, Andreas Walther, Martin Kräter, Clemens Kirschbaum, Wei Gao, Magdalena Wekenborg, Nicole Rothe, Jochen Gluck, Lucas Daniel Wittwer, Julian Eder

Department for Work, Organizational and Media Psychology

Research output: Working paper and reports › Preprint

Abstract

Continuously elevated depressive symptomatology as well as an increase in glucocorticoid levels over one year are associated with higher immune cell deformability, particularly in PDD. These findings suggest, that persistent depressive symptomatology associated with increased glucocorticoid secretion may lead to increased immune cell deformability thereby compromising immune cell function and likely contributing to the perpetuation of PDD.

Original language	English
Number of pages	71
DOIs	https://doi.org/10.1101/2022.09.23.22280275
Publication status	Published - Sept 2022

Publication series

Name	medRxiv

Fields of science

501012 Media psychology
501 Psychology
501003 Occupational psychology
501015 Organisational psychology

JKU Focus areas

Digital Transformation

Access to Document

10.1101/2022.09.23.22280275

Cite this

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abstract = "Continuously elevated depressive symptomatology as well as an increase in glucocorticoid levels over one year are associated with higher immune cell deformability, particularly in PDD. These findings suggest, that persistent depressive symptomatology associated with increased glucocorticoid secretion may lead to increased immune cell deformability thereby compromising immune cell function and likely contributing to the perpetuation of PDD.",

author = "Marlene Penz and Andreas Walther and Martin Kr{\"a}ter and Clemens Kirschbaum and Wei Gao and Magdalena Wekenborg and Nicole Rothe and Jochen Gluck and Wittwer, {Lucas Daniel} and Julian Eder",

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AU - Gao, Wei

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AU - Rothe, Nicole

AU - Gluck, Jochen

AU - Wittwer, Lucas Daniel

AU - Eder, Julian

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AB - Continuously elevated depressive symptomatology as well as an increase in glucocorticoid levels over one year are associated with higher immune cell deformability, particularly in PDD. These findings suggest, that persistent depressive symptomatology associated with increased glucocorticoid secretion may lead to increased immune cell deformability thereby compromising immune cell function and likely contributing to the perpetuation of PDD.

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