Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy

Peter Lanzerstorfer; Verena Stadlbauer; Lilia Chtcheglova; Renate Haselgrübler; Daniela Borgmann; Jürgen Wruss; Peter Hinterdorfer; Klaus Schröder; Stephan M. Winkler; O. Höglinger; Julian Weghuber

doi:10.1111/bph.12845

Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy

Peter Lanzerstorfer, Verena Stadlbauer, Lilia Chtcheglova, Renate Haselgrübler, Daniela Borgmann, Jürgen Wruss, Peter Hinterdorfer, Klaus Schröder, Stephan M. Winkler, O. Höglinger, Julian Weghuber

Department of Applied Experimental Biophysics

Research output: Contribution to journal › Article › peer-review

Abstract

Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is being paid to search for compounds that are able to enhance this translocation process in the absence of insulin.

Original language	English
Pages (from-to)	5237-5251
Number of pages	15
Journal	British Journal of Pharmacology
Volume	171
Issue number	23
DOIs	https://doi.org/10.1111/bph.12845
Publication status	Published - Dec 2014

Fields of science

103 Physics, Astronomy
106006 Biophysics

JKU Focus areas

Engineering and Natural Sciences (in general)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/bph.12845

Cite this

Lanzerstorfer, P., Stadlbauer, V., Chtcheglova, L., Haselgrübler, R., Borgmann, D., Wruss, J., Hinterdorfer, P., Schröder, K., Winkler, S. M., Höglinger, O., & Weghuber, J. (2014). Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy. British Journal of Pharmacology, 171(23), 5237-5251. https://doi.org/10.1111/bph.12845

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title = "Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy",

abstract = "Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is being paid to search for compounds that are able to enhance this translocation process in the absence of insulin.",

author = "Peter Lanzerstorfer and Verena Stadlbauer and Lilia Chtcheglova and Renate Haselgr{\"u}bler and Daniela Borgmann and J{\"u}rgen Wruss and Peter Hinterdorfer and Klaus Schr{\"o}der and Winkler, {Stephan M.} and O. H{\"o}glinger and Julian Weghuber",

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doi = "10.1111/bph.12845",

language = "English",

volume = "171",

pages = "5237--5251",

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Lanzerstorfer, P, Stadlbauer, V, Chtcheglova, L, Haselgrübler, R, Borgmann, D, Wruss, J, Hinterdorfer, P, Schröder, K, Winkler, SM, Höglinger, O & Weghuber, J 2014, 'Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy', British Journal of Pharmacology, vol. 171, no. 23, pp. 5237-5251. https://doi.org/10.1111/bph.12845

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T1 - Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy

AU - Lanzerstorfer, Peter

AU - Stadlbauer, Verena

AU - Chtcheglova, Lilia

AU - Haselgrübler, Renate

AU - Borgmann, Daniela

AU - Wruss, Jürgen

AU - Hinterdorfer, Peter

AU - Schröder, Klaus

AU - Winkler, Stephan M.

AU - Höglinger, O.

AU - Weghuber, Julian

PY - 2014/12

Y1 - 2014/12

N2 - Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is being paid to search for compounds that are able to enhance this translocation process in the absence of insulin.

AB - Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is being paid to search for compounds that are able to enhance this translocation process in the absence of insulin.

U2 - 10.1111/bph.12845

DO - 10.1111/bph.12845

M3 - Article

SN - 1476-5381

VL - 171

SP - 5237

EP - 5251

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 23

ER -