High Frequency QCM Flow Cell with Enhanced Accuracy for Liquid and Biochemical Sensing

Brigitte Paula Stehrer; Hermann Gruber; Reinhard Schwödiauer; Ingrid Graz; Siegfried Bauer

doi:10.1016/j.proche.2009.07.376

High Frequency QCM Flow Cell with Enhanced Accuracy for Liquid and Biochemical Sensing

Brigitte Paula Stehrer, Hermann Gruber, Reinhard Schwödiauer, Ingrid Graz, Siegfried Bauer

Research output: Contribution to journal › Article › peer-review

Abstract

Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. The utilisation of high frequency fundamental (HFF) quartz resonators could further improve the sensitivity of such systems. We designed an acoustic biosensor flow cell for HFF quartz resonators. For the development of a biosensor we solved important questions like the functionalization of the small and fragile sensor surface, the sensitive and repeatable detection of dissolved analytes and the regeneration of the sensor. The system performance is evaluated by a number of experiments including the stepwise growth of a protein multilayer system.

Original language	English
Pages (from-to)	1507-1510
Number of pages	4
Journal	Procedia Chemistry
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.proche.2009.07.376
Publication status	Published - 2009

Fields of science

103015 Condensed matter
103 Physics, Astronomy
103008 Experimental physics
103023 Polymer physics
103018 Materials physics
202036 Sensor systems
202022 Information technology

JKU Focus areas

Nano-, Bio- and Polymer-Systems: From Structure to Function
Engineering and Natural Sciences (in general)

Access to Document

10.1016/j.proche.2009.07.376

Cite this

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title = "High Frequency QCM Flow Cell with Enhanced Accuracy for Liquid and Biochemical Sensing",

abstract = "Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. The utilisation of high frequency fundamental (HFF) quartz resonators could further improve the sensitivity of such systems. We designed an acoustic biosensor flow cell for HFF quartz resonators. For the development of a biosensor we solved important questions like the functionalization of the small and fragile sensor surface, the sensitive and repeatable detection of dissolved analytes and the regeneration of the sensor. The system performance is evaluated by a number of experiments including the stepwise growth of a protein multilayer system.",

author = "Stehrer, {Brigitte Paula} and Hermann Gruber and Reinhard Schw{\"o}diauer and Ingrid Graz and Siegfried Bauer",

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AU - Stehrer, Brigitte Paula

AU - Gruber, Hermann

AU - Schwödiauer, Reinhard

AU - Graz, Ingrid

AU - Bauer, Siegfried

PY - 2009

Y1 - 2009

N2 - Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. The utilisation of high frequency fundamental (HFF) quartz resonators could further improve the sensitivity of such systems. We designed an acoustic biosensor flow cell for HFF quartz resonators. For the development of a biosensor we solved important questions like the functionalization of the small and fragile sensor surface, the sensitive and repeatable detection of dissolved analytes and the regeneration of the sensor. The system performance is evaluated by a number of experiments including the stepwise growth of a protein multilayer system.

AB - Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. The utilisation of high frequency fundamental (HFF) quartz resonators could further improve the sensitivity of such systems. We designed an acoustic biosensor flow cell for HFF quartz resonators. For the development of a biosensor we solved important questions like the functionalization of the small and fragile sensor surface, the sensitive and repeatable detection of dissolved analytes and the regeneration of the sensor. The system performance is evaluated by a number of experiments including the stepwise growth of a protein multilayer system.

U2 - 10.1016/j.proche.2009.07.376

DO - 10.1016/j.proche.2009.07.376

M3 - Article

SN - 1876-6196

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JO - Procedia Chemistry

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