High frequency QCM based sensor system for sensitive detection of dissolved analytes

Brigitte Paula Stehrer; Reinhard Schwödiauer; Siegfried Bauer; Ingrid Graz; Philipp Pollheimer; Hermann Gruber

doi:10.1016/j.proeng.2010.09.238

High frequency QCM based sensor system for sensitive detection of dissolved analytes

Brigitte Paula Stehrer, Reinhard Schwödiauer, Siegfried Bauer, Ingrid Graz, Philipp Pollheimer, Hermann Gruber

Research output: Contribution to journal › Article › peer-review

Abstract

The quartz crystal microbalance (QCM) has proven to be a highly sensitive mass detector which found its way into biomedical sciences [1, 2]. Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. Utilization of high fundamental frequency (HFF) quartz resonators can further improve the sensitivity of such systems. In order to exploit this enhanced sensitivity for acoustic biosensing, we have designed a flow cell for HFF quartz resonators and introduced a gentle functionalization method for the small and fragile sensor surface. The resulting biosensor afforded sensitive and reproducible detection of dissolved analytes and allowed for rapid in-situ regeneration of the sensor surface.

Original language	English
Pages (from-to)	835-837
Number of pages	3
Journal	Procedia Engineering
Volume	5
DOIs	https://doi.org/10.1016/j.proeng.2010.09.238
Publication status	Published - 2010

Fields of science

103015 Condensed matter
103 Physics, Astronomy
103008 Experimental physics
103023 Polymer physics
103018 Materials physics
202036 Sensor systems
202022 Information technology

JKU Focus areas

Nano-, Bio- and Polymer-Systems: From Structure to Function
Engineering and Natural Sciences (in general)

Access to Document

10.1016/j.proeng.2010.09.238

Cite this

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title = "High frequency QCM based sensor system for sensitive detection of dissolved analytes",

abstract = "The quartz crystal microbalance (QCM) has proven to be a highly sensitive mass detector which found its way into biomedical sciences [1, 2]. Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. Utilization of high fundamental frequency (HFF) quartz resonators can further improve the sensitivity of such systems. In order to exploit this enhanced sensitivity for acoustic biosensing, we have designed a flow cell for HFF quartz resonators and introduced a gentle functionalization method for the small and fragile sensor surface. The resulting biosensor afforded sensitive and reproducible detection of dissolved analytes and allowed for rapid in-situ regeneration of the sensor surface.",

author = "Stehrer, \{Brigitte Paula\} and Reinhard Schw{\"o}diauer and Siegfried Bauer and Ingrid Graz and Philipp Pollheimer and Hermann Gruber",

year = "2010",

doi = "10.1016/j.proeng.2010.09.238",

language = "English",

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journal = "Procedia Engineering",

issn = "1877-7058",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - High frequency QCM based sensor system for sensitive detection of dissolved analytes

AU - Stehrer, Brigitte Paula

AU - Schwödiauer, Reinhard

AU - Bauer, Siegfried

AU - Graz, Ingrid

AU - Pollheimer, Philipp

AU - Gruber, Hermann

PY - 2010

Y1 - 2010

N2 - The quartz crystal microbalance (QCM) has proven to be a highly sensitive mass detector which found its way into biomedical sciences [1, 2]. Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. Utilization of high fundamental frequency (HFF) quartz resonators can further improve the sensitivity of such systems. In order to exploit this enhanced sensitivity for acoustic biosensing, we have designed a flow cell for HFF quartz resonators and introduced a gentle functionalization method for the small and fragile sensor surface. The resulting biosensor afforded sensitive and reproducible detection of dissolved analytes and allowed for rapid in-situ regeneration of the sensor surface.

AB - The quartz crystal microbalance (QCM) has proven to be a highly sensitive mass detector which found its way into biomedical sciences [1, 2]. Most biosensing systems based on thickness shear mode resonators work with resonance frequencies between 5 and 20 MHz. Utilization of high fundamental frequency (HFF) quartz resonators can further improve the sensitivity of such systems. In order to exploit this enhanced sensitivity for acoustic biosensing, we have designed a flow cell for HFF quartz resonators and introduced a gentle functionalization method for the small and fragile sensor surface. The resulting biosensor afforded sensitive and reproducible detection of dissolved analytes and allowed for rapid in-situ regeneration of the sensor surface.

U2 - 10.1016/j.proeng.2010.09.238

DO - 10.1016/j.proeng.2010.09.238

M3 - Article

SN - 1877-7058

VL - 5

SP - 835

EP - 837

JO - Procedia Engineering

JF - Procedia Engineering

ER -