Filtering and Identifying non-reliable probes in Affymetrix GeneChip® platforms

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Abstract

Non-reliable/bad probes of oligonucleotide microarrays fail to spot signals which are detected and by the majority of probes in a probe set. We predict “bad” probes from the nucleotide sequence using SVMs and spectrum kernels with accuracies between 60 and 75% where, surprisingly, the models generalize to other platforms.
Original languageEnglish
Title of host publicationISMB 2009 Proceedings
Number of pages1
Publication statusPublished - Jun 2009

Fields of science

  • 101004 Biomathematics
  • 101027 Dynamical systems
  • 101028 Mathematical modelling
  • 101029 Mathematical statistics
  • 101014 Numerical mathematics
  • 101015 Operations research
  • 101016 Optimisation
  • 101017 Game theory
  • 101018 Statistics
  • 101019 Stochastics
  • 101024 Probability theory
  • 101026 Time series analysis
  • 102 Computer Sciences
  • 102001 Artificial intelligence
  • 102003 Image processing
  • 102004 Bioinformatics
  • 102013 Human-computer interaction
  • 102018 Artificial neural networks
  • 102019 Machine learning
  • 103029 Statistical physics
  • 106005 Bioinformatics
  • 106007 Biostatistics
  • 202017 Embedded systems
  • 202035 Robotics
  • 202036 Sensor systems
  • 202037 Signal processing
  • 305901 Computer-aided diagnosis and therapy
  • 305905 Medical informatics
  • 305907 Medical statistics
  • 102032 Computational intelligence
  • 102033 Data mining
  • 101031 Approximation theory

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