Fast and Flexible Drug Screening Using a Pure Hydrodynamic Droplet Control

In this work, we review the concept for a pure hydrodynamic droplet control in a microfludic bus network. With this approach, single or multiple droplets can be routed to a desired target. Moreover, multiple droplets can be routed to multiple targets, enabling parallel processing. In both cases, the destination address is encoded in the distance between the droplets. Afterwards, we apply this concept to realize a microfluidic design, which performs screening of different antibiotics and concentrations on lung cells infected with a bacteria. The resulting design allows for a fast and flexible drug screening and can be fabricated at low-cost.