Abstract
Biclustering of transcriptomic data groups genes and samples simultaneously. It is emerging as a standard tool for extracting knowledge from gene expression measurements. We propose a novel generative approach for biclustering called ‘FABIA: Factor Analysis for Bicluster Acquisition’. FABIA is based on a multiplicative model, which accounts for linear dependencies between gene expression and conditions, and also captures heavy-tailed distributions as observed in real-world transcriptomic data. The generative framework allows to utilize well-founded model selection methods and to apply Bayesian techniques.
| Original language | English |
|---|---|
| Article number | btq227 |
| Pages (from-to) | 1520-1527 |
| Number of pages | 8 |
| Journal | Bioinformatics |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 23 Apr 2010 |
Fields of science
- 101004 Biomathematics
- 101027 Dynamical systems
- 101028 Mathematical modelling
- 101029 Mathematical statistics
- 101014 Numerical mathematics
- 101015 Operations research
- 101016 Optimisation
- 101017 Game theory
- 101018 Statistics
- 101019 Stochastics
- 101024 Probability theory
- 101026 Time series analysis
- 102 Computer Sciences
- 102001 Artificial intelligence
- 102003 Image processing
- 102004 Bioinformatics
- 102013 Human-computer interaction
- 102018 Artificial neural networks
- 102019 Machine learning
- 103029 Statistical physics
- 106005 Bioinformatics
- 106007 Biostatistics
- 202017 Embedded systems
- 202035 Robotics
- 202036 Sensor systems
- 202037 Signal processing
- 305901 Computer-aided diagnosis and therapy
- 305905 Medical informatics
- 305907 Medical statistics
- 102032 Computational intelligence
- 102033 Data mining
- 101031 Approximation theory