TY - JOUR
T1 - Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage
AU - Rass, Verena
AU - Helbok, Raimund
PY - 2019/8/29
Y1 - 2019/8/29
N2 - PURPOSE OF REVIEW: Over the last years, the focus of clinical and animal research in subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based on the association of the early injury pattern (first 72 h) with secondary complications and poor outcome. This phase is commonly referenced as early brain injury (EBI). In this clinical review, we intended to overview commonly used definitions of EBI, underlying mechanisms, and potential treatment implications.RECENT FINDINGS: We found a large heterogeneity in the definition used for EBI comprising clinical symptoms, neuroimaging parameters, and advanced neuromonitoring techniques. Although specific treatments are currently not available, therapeutic interventions are aimed at ameliorating EBI by improving the energy/supply mismatch in the early phase after SAH. Future research integrating brain-derived biomarkers is warranted to improve our pathophysiologic understanding of EBI in order to ameliorate early injury patterns and improve patients' outcomes.
AB - PURPOSE OF REVIEW: Over the last years, the focus of clinical and animal research in subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based on the association of the early injury pattern (first 72 h) with secondary complications and poor outcome. This phase is commonly referenced as early brain injury (EBI). In this clinical review, we intended to overview commonly used definitions of EBI, underlying mechanisms, and potential treatment implications.RECENT FINDINGS: We found a large heterogeneity in the definition used for EBI comprising clinical symptoms, neuroimaging parameters, and advanced neuromonitoring techniques. Although specific treatments are currently not available, therapeutic interventions are aimed at ameliorating EBI by improving the energy/supply mismatch in the early phase after SAH. Future research integrating brain-derived biomarkers is warranted to improve our pathophysiologic understanding of EBI in order to ameliorate early injury patterns and improve patients' outcomes.
KW - Animals
KW - Brain Injuries/complications
KW - Early Diagnosis
KW - Humans
KW - Subarachnoid Hemorrhage/complications
KW - Terminology as Topic
UR - https://www.scopus.com/pages/publications/85071449903
U2 - 10.1007/s11910-019-0990-3
DO - 10.1007/s11910-019-0990-3
M3 - Review article
C2 - 31468197
SN - 1528-4042
VL - 19
SP - 78
JO - Current neurology and neuroscience reports
JF - Current neurology and neuroscience reports
IS - 10
M1 - 78
ER -