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Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration

  • Sandra Rothemund
  • , Tamara Aigner
  • , Aitziber Iturmendi
  • , Maria Rigau
  • , Branislav Husár
  • , Florian Hildner
  • , Eleni Oberbauer
  • , Martina Prambauer
  • , Gbenga Olawale
  • , Reinhard Forstner
  • , Robert Liska
  • , Klaus Schröder
  • , Oliver Brüggemann
  • , Ian Teasdale

Research output: Contribution to journalArticlepeer-review

Abstract

Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.
Original languageEnglish
Pages (from-to)351-363
Number of pages13
JournalMacromolecular Bioscience
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2015

Fields of science

  • 304007 Tissue engineering
  • 204002 Chemical reaction engineering
  • 210004 Nanomaterials
  • 104 Chemistry
  • 104002 Analytical chemistry
  • 104011 Materials chemistry
  • 104014 Surface chemistry
  • 104016 Photochemistry
  • 104018 Polymer chemistry
  • 104008 Catalysis
  • 104010 Macromolecular chemistry
  • 104015 Organic chemistry
  • 104019 Polymer sciences
  • 106002 Biochemistry
  • 107002 Bionics
  • 301305 Medical chemistry
  • 301207 Pharmaceutical chemistry
  • 301904 Cancer research
  • 302009 Chemotherapy

JKU Focus areas

  • Nano-, Bio- and Polymer-Systems: From Structure to Function
  • Engineering and Natural Sciences (in general)

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