Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration

Sandra Rothemund; Tamara Aigner; Aitziber Iturmendi; Maria Rigau; Branislav Husár; Florian Hildner; Eleni Oberbauer; Martina Prambauer; Gbenga Olawale; Reinhard Forstner; Robert Liska; Klaus Schröder; Oliver Brüggemann; Ian Teasdale

doi:10.1002/mabi.201400390

Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration

Sandra Rothemund, Tamara Aigner, Aitziber Iturmendi, Maria Rigau, Branislav Husár, Florian Hildner, Eleni Oberbauer, Martina Prambauer, Gbenga Olawale, Reinhard Forstner, Robert Liska, Klaus Schröder, Oliver Brüggemann, Ian Teasdale

Institute of Polymer Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.

Original language	English
Journal	Macromolecular Bioscience
DOIs	https://doi.org/10.1002/mabi.201400390
Publication status	Published - Oct 2015

Fields of science

304007 Tissue engineering
204002 Chemical reaction engineering
210004 Nanomaterials
104 Chemistry
104002 Analytical chemistry
104011 Materials chemistry
104014 Surface chemistry
104016 Photochemistry
104018 Polymer chemistry
104008 Catalysis
104010 Macromolecular chemistry
104015 Organic chemistry
104019 Polymer sciences
106002 Biochemistry
107002 Bionics
301305 Medical chemistry
301207 Pharmaceutical chemistry
301904 Cancer research
302009 Chemotherapy

JKU Focus areas

Nano-, Bio- and Polymer-Systems: From Structure to Function
Engineering and Natural Sciences (in general)

Access to Document

10.1002/mabi.201400390

Cite this

Rothemund, S., Aigner, T., Iturmendi, A., Rigau, M., Husár, B., Hildner, F., Oberbauer, E., Prambauer, M., Olawale, G., Forstner, R., Liska, R., Schröder, K., Brüggemann, O., & Teasdale, I. (2015). Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration. Macromolecular Bioscience. https://doi.org/10.1002/mabi.201400390

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abstract = "Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.",

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AU - Rothemund, Sandra

AU - Aigner, Tamara

AU - Iturmendi, Aitziber

AU - Rigau, Maria

AU - Husár, Branislav

AU - Hildner, Florian

AU - Oberbauer, Eleni

AU - Prambauer, Martina

AU - Olawale, Gbenga

AU - Forstner, Reinhard

AU - Liska, Robert

AU - Schröder, Klaus

AU - Brüggemann, Oliver

AU - Teasdale, Ian

PY - 2015/10

Y1 - 2015/10

N2 - Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.

AB - Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.

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DO - 10.1002/mabi.201400390

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SN - 1616-5187

JO - Macromolecular Bioscience

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