Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report

Klaus Berek; Ronny Beer; Astrid Grams; Raimund Helbok; Anna Lindner; Bettina Pfausler; Alois Schiefecker; Florian Deisenhammer; Harald Hegen

doi:10.1186/s12883-022-02637-x

Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report

Klaus Berek, Ronny Beer, Astrid Grams, Raimund Helbok, Anna Lindner, Bettina Pfausler, Alois Schiefecker, Florian Deisenhammer, Harald Hegen

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.

CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).

CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.

Original language	English
Article number	131
Pages (from-to)	131
Journal	BMC Neurology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12883-022-02637-x
Publication status	Published - 05 Apr 2022
Externally published	Yes

Fields of science

302 Clinical Medicine

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title = "Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report",

abstract = "BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.",

keywords = "Aged, 80 and over, Autoantibodies/cerebrospinal fluid, Autoimmunity, Electroencephalography, Encephalitis, Herpes Simplex/complications, Female, Herpes Simplex/complications, Humans, Magnetic Resonance Imaging",

author = "Klaus Berek and Ronny Beer and Astrid Grams and Raimund Helbok and Anna Lindner and Bettina Pfausler and Alois Schiefecker and Florian Deisenhammer and Harald Hegen",

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T1 - Caspr2 antibodies in herpes simplex encephalitis

T2 - an extension of the spectrum of virus induced autoimmunity? - A case report

AU - Berek, Klaus

AU - Beer, Ronny

AU - Grams, Astrid

AU - Helbok, Raimund

AU - Lindner, Anna

AU - Pfausler, Bettina

AU - Schiefecker, Alois

AU - Deisenhammer, Florian

AU - Hegen, Harald

PY - 2022/4/5

Y1 - 2022/4/5

N2 - BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.

AB - BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.

KW - Aged, 80 and over

KW - Autoantibodies/cerebrospinal fluid

KW - Autoimmunity

KW - Electroencephalography

KW - Encephalitis, Herpes Simplex/complications

KW - Female

KW - Herpes Simplex/complications

KW - Humans

KW - Magnetic Resonance Imaging

UR - https://www.scopus.com/pages/publications/85127611063

U2 - 10.1186/s12883-022-02637-x

DO - 10.1186/s12883-022-02637-x

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C2 - 35382753

SN - 1471-2377

VL - 22

SP - 131

JO - BMC Neurology

JF - BMC Neurology

IS - 1

M1 - 131

ER -

Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report

Abstract

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