Abstract
Store-operated Ca2+ entry describes the phenomenon that connects a depletion of internal Ca2+ stores to an activation of plasma membrane-located Ca2+ selective ion channels. Tremendous progress towards the underlying molecular mechanism came with the discovery of the two respective limiting components, STIM and Orai. STIM1 represents the ER-located Ca2+ sensor and transmits the signal of store depletion to the plasma membrane. Here it couples to and activates Orai, the highly Ca2+-selective pore-forming subunit of Ca2+ release-activated Ca2+ channels. In this review, we focus on the molecular steps that these two proteins undergo from store-depletion to their coupling, the activation, and regulation of Ca2+ currents.
| Original language | English |
|---|---|
| Pages (from-to) | 4163-4176 |
| Number of pages | 14 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 69 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 2012 |
Fields of science
- 103036 Theoretical physics
- 211904 Biomechanics
- 103020 Surface physics
- 210 Nanotechnology
- 104010 Macromolecular chemistry
- 106006 Biophysics
- 106022 Microbiology
- 106048 Animal physiology
- 209 Industrial Biotechnology
- 304 Medical Biotechnology
- 404 Agricultural Biotechnology, Food Biotechnology
- 106049 Ultrastructure research
- 103021 Optics
- 106002 Biochemistry
- 104017 Physical chemistry
- 208 Environmental Biotechnology
- 104014 Surface chemistry
- 106023 Molecular biology
- 107 Other Natural Sciences
- 301110 Physiology
- 301206 Pharmacology
- 206 Medical Engineering
- 301306 Medical molecular biology
- 302044 Medical physics
- 301902 Immunology
- 305910 Traffic medicine
JKU Focus areas
- Engineering and Natural Sciences (in general)