TY - JOUR
T1 - Axon initial segment dynamics during associative fear learning
AU - Benoit, Chloé Maëlle
AU - Ganea, Dan Alin
AU - Paricio-Montesinos, Ricardo
AU - Esser, Julia
AU - Thome, Christian
AU - Janssen, Jan Maximilian
AU - Sattin, Andrea
AU - Innocenti, Sabrina Milena
AU - Krabbe, Sabine
AU - Lüthi, Andreas
AU - Fellin, Tommaso
AU - Engelhardt, Maren
AU - Gründemann, Jan
N1 - © 2025. The Author(s).
PY - 2025/12/23
Y1 - 2025/12/23
N2 - The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
AB - The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
UR - https://www.scopus.com/pages/publications/105025769168
U2 - 10.1038/s41593-025-02152-5
DO - 10.1038/s41593-025-02152-5
M3 - Article
C2 - 41436652
SN - 1546-1726
JO - Nature Neuroscience
JF - Nature Neuroscience
ER -