A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

Constanze Lamprecht; Mohammadreza Taale; Ingo Paulowicz; Hannes Westerhaus; Carsten Grabosch; Arnim Suchardt; Matthias Mecklenburg; Martina Böttner; Ralph Lucius; Karl Schulte; Rainer Adelung; Christine Selhuber-Unkel

doi:10.1021/acsami.6b00778

A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

Constanze Lamprecht
, Mohammadreza Taale
, Ingo Paulowicz
, Hannes Westerhaus
, Carsten Grabosch
, Arnim Suchardt
, Matthias Mecklenburg
, Martina Böttner
, Ralph Lucius
, Karl Schulte
, Rainer Adelung
, Christine Selhuber-Unkel

Department of Applied Experimental Biophysics

Research output: Contribution to journal › Article › peer-review

Abstract

Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days

Original language	English
Pages (from-to)	14980–14985
Number of pages	6
Journal	ACS Applied Materials & Interfaces
Volume	8
Issue number	24
DOIs	https://doi.org/10.1021/acsami.6b00778
Publication status	Published - 2016

Fields of science

103 Physics, Astronomy
106006 Biophysics

JKU Focus areas

Engineering and Natural Sciences (in general)

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10.1021/acsami.6b00778

Cite this

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title = "A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth",

abstract = "Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days",

author = "Constanze Lamprecht and Mohammadreza Taale and Ingo Paulowicz and Hannes Westerhaus and Carsten Grabosch and Arnim Suchardt and Matthias Mecklenburg and Martina B{\"o}ttner and Ralph Lucius and Karl Schulte and Rainer Adelung and Christine Selhuber-Unkel",

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doi = "10.1021/acsami.6b00778",

language = "English",

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T1 - A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

AU - Lamprecht, Constanze

AU - Taale, Mohammadreza

AU - Paulowicz, Ingo

AU - Westerhaus, Hannes

AU - Grabosch, Carsten

AU - Suchardt, Arnim

AU - Mecklenburg, Matthias

AU - Böttner, Martina

AU - Lucius, Ralph

AU - Schulte, Karl

AU - Adelung, Rainer

AU - Selhuber-Unkel, Christine

PY - 2016

Y1 - 2016

N2 - Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days

AB - Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days

UR - https://www.scopus.com/pages/publications/84975806540

U2 - 10.1021/acsami.6b00778

DO - 10.1021/acsami.6b00778

M3 - Article

SN - 1944-8244

VL - 8

SP - 14980

EP - 14985

JO - ACS Applied Materials & Interfaces

JF - ACS Applied Materials & Interfaces

IS - 24

ER -

A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

Abstract

Fields of science

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