Abstract
We propose a new model-based technique for summarizing high-density oligonucleotide array data at probe level for Affymetrix GeneChips. The new summarization method is based on a factor analysis model for which a Bayesian maximum a posteriori method optimizes the model parameters under the assumption of Gaussian measurement noise. Thereafter, the RNA concentration is estimated from the model. In contrast to previous methods our new method called Factor Analysis for Robust Microarray Summarization (FARMS) supplies both P-values indicating interesting information and signal intensity values.
| Original language | English |
|---|---|
| Pages (from-to) | 943-949 |
| Number of pages | 7 |
| Journal | Bioinformatics |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 2006 |
Fields of science
- 101004 Biomathematics
- 101027 Dynamical systems
- 101028 Mathematical modelling
- 101029 Mathematical statistics
- 101014 Numerical mathematics
- 101015 Operations research
- 101016 Optimisation
- 101017 Game theory
- 101018 Statistics
- 101019 Stochastics
- 101024 Probability theory
- 101026 Time series analysis
- 102 Computer Sciences
- 102001 Artificial intelligence
- 102003 Image processing
- 102004 Bioinformatics
- 102013 Human-computer interaction
- 102018 Artificial neural networks
- 102019 Machine learning
- 103029 Statistical physics
- 106005 Bioinformatics
- 106007 Biostatistics
- 202017 Embedded systems
- 202035 Robotics
- 202036 Sensor systems
- 202037 Signal processing
- 305901 Computer-aided diagnosis and therapy
- 305905 Medical informatics
- 305907 Medical statistics
- 102032 Computational intelligence
- 102033 Data mining
- 101031 Approximation theory