A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Sunil V. Rao; Bodo Kirsch; Deepak L. Bhatt; Andrzej Budaj; Rosa Coppolecchia; John Eikelboom; Stefan James; W. Schuyler Jones; Bela Merkely; Lars Keller; Renicus S. Hermanides; Gianluca Campo; José Luis Ferreiro; Taro Shibasaki; Hardi Mundl; John H. Alexander; Christian Hengstenberg; the PACIFIC AMI Investigators

doi:10.1161/CIRCULATIONAHA.122.061612

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Sunil V. Rao^*
, Bodo Kirsch
, Deepak L. Bhatt
, Andrzej Budaj
, Rosa Coppolecchia
, John Eikelboom
, Stefan James
, W. Schuyler Jones
, Bela Merkely
, Lars Keller
, Renicus S. Hermanides
, Gianluca Campo
, José Luis Ferreiro
, Taro Shibasaki
, Hardi Mundl
, John H. Alexander
, Christian Hengstenberg (Study Group Member)
, the PACIFIC AMI Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1196-1206
Number of pages	11
Journal	Circulation
Volume	146
Issue number	16
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.122.061612
Publication status	Published - 18 Oct 2022

Fields of science

302031 Intensive care medicine
302032 Cardiology
302030 Internal medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/CIRCULATIONAHA.122.061612

Cite this

Rao, S. V., Kirsch, B., Bhatt, D. L., Budaj, A., Coppolecchia, R., Eikelboom, J., James, S., Jones, W. S., Merkely, B., Keller, L., Hermanides, R. S., Campo, G., Ferreiro, J. L., Shibasaki, T., Mundl, H., Alexander, J. H., Hengstenberg, C., & the PACIFIC AMI Investigators (2022). A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction. Circulation, 146(16), 1196-1206. https://doi.org/10.1161/CIRCULATIONAHA.122.061612

@article{490a0f9eed2d4f5c89c86d4d59f3887d,

title = "A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction",

keywords = "anticoagulants, factor XIa, myocardial infarction",

author = "Rao, \{Sunil V.\} and Bodo Kirsch and Bhatt, \{Deepak L.\} and Andrzej Budaj and Rosa Coppolecchia and John Eikelboom and Stefan James and Jones, \{W. Schuyler\} and Bela Merkely and Lars Keller and Hermanides, \{Renicus S.\} and Gianluca Campo and Ferreiro, \{Jos{\'e} Luis\} and Taro Shibasaki and Hardi Mundl and Alexander, \{John H.\} and Christian Hengstenberg and Clemens Steinwender and Hannes Alber and Regina Steringer-Mascherbauer and Andreas Schober and Johann Auer and Roithinger, \{Franz Xaver\} and \{Von Lewinski\}, Dirk and Deddo Moertl and Kurt Huber and Patrick Coussement and Etienne Hoffer and Christophe Beauloye and Luc Janssens and Pascal Vranckx and \{De Raedt\}, Herbert and Thomas Vanassche and Matthias Vrolix and Richard Rokyta and Jiri Parenica and Radek Pelouch and Zuzanna Motovska and David Alan and Jiri Kettner and Rostislav Polasek and Ondrej Cermak and Pavel Sedlon and Jiri Hanis and Martin Novak and Jan Belohlavek and Thomas Horacek and Stefan Leggewie and Philip Wenzel and \{Vom Dahl\}, Juergen and \{et al.\} and \{the PACIFIC AMI Investigators\}",

note = "Publisher Copyright: {\textcopyright} 2022 American Heart Association, Inc.",

year = "2022",

month = oct,

day = "18",

doi = "10.1161/CIRCULATIONAHA.122.061612",

language = "English",

volume = "146",

pages = "1196--1206",

journal = "Circulation",

issn = "0009-7322",

number = "16",

}

Rao, SV, Kirsch, B, Bhatt, DL, Budaj, A, Coppolecchia, R, Eikelboom, J, James, S, Jones, WS, Merkely, B, Keller, L, Hermanides, RS, Campo, G, Ferreiro, JL, Shibasaki, T, Mundl, H, Alexander, JH, Hengstenberg, C & the PACIFIC AMI Investigators 2022, 'A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction', Circulation, vol. 146, no. 16, pp. 1196-1206. https://doi.org/10.1161/CIRCULATIONAHA.122.061612

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction. / Rao, Sunil V.; Kirsch, Bodo; Bhatt, Deepak L. et al.
In: Circulation, Vol. 146, No. 16, 18.10.2022, p. 1196-1206.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

AU - Rao, Sunil V.

AU - Kirsch, Bodo

AU - Bhatt, Deepak L.

AU - Budaj, Andrzej

AU - Coppolecchia, Rosa

AU - Eikelboom, John

AU - James, Stefan

AU - Jones, W. Schuyler

AU - Merkely, Bela

AU - Keller, Lars

AU - Hermanides, Renicus S.

AU - Campo, Gianluca

AU - Ferreiro, José Luis

AU - Shibasaki, Taro

AU - Mundl, Hardi

AU - Alexander, John H.

AU - the PACIFIC AMI Investigators

A2 - Hengstenberg, Christian

A2 - Steinwender, Clemens

A2 - Alber, Hannes

A2 - Steringer-Mascherbauer, Regina

A2 - Schober, Andreas

A2 - Auer, Johann

A2 - Roithinger, Franz Xaver

A2 - Von Lewinski, Dirk

A2 - Moertl, Deddo

A2 - Huber, Kurt

A2 - Coussement, Patrick

A2 - Hoffer, Etienne

A2 - Beauloye, Christophe

A2 - Janssens, Luc

A2 - Vranckx, Pascal

A2 - De Raedt, Herbert

A2 - Vanassche, Thomas

A2 - Vrolix, Matthias

A2 - Rokyta, Richard

A2 - Parenica, Jiri

A2 - Pelouch, Radek

A2 - Motovska, Zuzanna

A2 - Alan, David

A2 - Kettner, Jiri

A2 - Polasek, Rostislav

A2 - Cermak, Ondrej

A2 - Sedlon, Pavel

A2 - Hanis, Jiri

A2 - Novak, Martin

A2 - Belohlavek, Jan

A2 - Horacek, Thomas

A2 - Leggewie, Stefan

A2 - Wenzel, Philip

A2 - Vom Dahl, Juergen

A2 - et al.,

PY - 2022/10/18

Y1 - 2022/10/18

KW - anticoagulants

KW - factor XIa

KW - myocardial infarction

UR - https://www.scopus.com/pages/publications/85139497397

U2 - 10.1161/CIRCULATIONAHA.122.061612

DO - 10.1161/CIRCULATIONAHA.122.061612

M3 - Article

C2 - 36030390

AN - SCOPUS:85139497397

SN - 0009-7322

VL - 146

SP - 1196

EP - 1206

JO - Circulation

JF - Circulation

IS - 16

ER -

Rao SV, Kirsch B, Bhatt DL, Budaj A, Coppolecchia R, Eikelboom J et al. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction. Circulation. 2022 Oct 18;146(16):1196-1206. doi: 10.1161/CIRCULATIONAHA.122.061612

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Fields of science

UN SDGs

Access to Document

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Cite this