Novel Signaling Pathways of vascular calcification

Medial vascular calcification is an active process, mediated by vascular smooth muscle cells. This process is closely associated with an increased risk of cardiovascular events and is especially involved in the high cardiovascular mortality of chronic kidney disease patients. Until now, no established therapeutic strategy exists to reduce vascular calcification. This project aims to identify unknown mechanisms underlying the process of vascular calcification, which may be suitable as therapeutic targets.of medial vascular calcification. These signaling pathways could be of crucial importance as pharmacological targets.