Adenomyosis and endometrial cancer - exploratory study

In interdisciplinary collaboration with the Institute of Pathology and Molecular Biology of the JKU Linz, the association between adenomyosis and the occurrence of endometroid endometrial carcinoma will be investigated using existing hysterectomy specimens. The prevalence of adenomyosis among patients with endometrial carcinoma is 22.6%. Preparations of endometroid endometrial carcinoma will be re-examined and measured morphometrically. Tissue micro arrays will be used to perform immunohistochemical studies. One of the aims of the study is to evaluate the expression patterns of immunohistochemical markers and to determine the incidence of the markers and the incidence of adenomyosis and endometroid carcinoma. In addition, particularly suitable cases are divided into 8 groups (adenomyosis from adenomyosis case, adenomyosis from tumor case, inconspicuous endometrium etc). Approximately 10 samples per group are used for this purpose. These are sent to HTG Molecular Diagnostics to investigate gene expression. Since the specimens are labeled exclusively with the histology order number, it is not possible for the employees of HTG not possible to trace the corresponding patient. We will examine the genes found in the RNA sequence analysis for significant differences between the groups and then link them to clinical data.