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Isabella Derler

Assoz.Univprof., DI Dr.

  • Institute of Biophysics
  • Department of Molecular and Membrane Biophysics
 https://orcid.org/0000-0002-4768-146X
  • EmailIsabella.Derlerjkuat
  • Overview
  • Network
  • Research output (51)
  • Projects (10)
  • Activities (4)

Research output

  • 50 Article
  • 1 Research report

Research output per year

Research output per year

  • STIM1-induced widening of non-pore-lining TM interfaces is crucial for Orai1 pore opening

    Najjar, H., Weiß, S., Horvath, F., Hopl, V., Tiffner, A., Höbarth, L., Söllner, J., Fröhlich, M., Prantl, M., Müller, N., Nazarenko, Y., Harant, S., Weissenböck, L., Grabmayr, H., Sallinger, M., Maltan, L., Echefu, L. V., Radiskovic, T., Leopold, M. & Lindinger, S. & 5 others, Humer, C., Höglinger, C., Krobath, H., Renger, T. & Derler, I., 18 Jun 2025, In: Cell Reports Physical Science. 6, 6, 23 p., 102623.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • Activation mechanisms and structural dynamics of STIM proteins

    Sallinger, M., Grabmayr, H., Humer, C., Bonhenry, D., Romanin, C., Schindl, R. & Derler, I., 15 Apr 2024, In: The Journal of Physiology. 602, 8, p. 1475-1507 33 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • Genetic code expansion, an emerging tool in the Ca2+ ion channel field

    Söllner, J. & Derler, I., 15 Jul 2024, In: Journal of Physiology. 602, 14, p. 3297-3313 17 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • Water in peripheral TM-interfaces of Orai1-channels triggers pore opening

    Hopl, V., Tiffner, A., Wutscher, A., Sallinger, M., Grabmayr, H., Prantl, M., Fröhlich, M., Söllner, J., Weiß, S., Najjar, H., Nazarenko, Y., Harant, S., Krisko, N., Fahrner, M., Humer, C., Höglinger, C., Krobath, H., Bonhenry, D. & Derler, I., 16 Nov 2024, In: Communications Biology. 7, 1, 16 p., 1522.

    Research output: Contribution to journal › Article

    Open Access
  • CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development

    Tiffner, A., Hopl, V. & Derler, I., Jan 2023, In: Cancers. 15, 1, p. Cancers 2023, 15(1), 101 49 p., 101.

    Research output: Contribution to journal › Article

    Open Access
View all 51 research outputs

Projects

  • 1 Not started
  • 2 Active
  • 7 Finished

Projects per year

  • Novel insights in CRAC Channels by genetic code expansion

    Derler, I. (PI)

    01.01.2023 → 31.12.2026

    Project: Funded research › FWF - Austrian Science Fund

  • Dynamik des Orai1-Kanals, die die Porenöffnung bestimmt

    Derler, I. (PI)

    01.10.2022 → 30.09.2026

    Project: Funded research › FWF - Austrian Science Fund

  • Role of cholesterol in the regulation of SK3 K+ currents

    Derler, I. (Researcher)

    01.09.2026 → 31.08.2030

    Project: Funded research › FWF - Austrian Science Fund

  • Wechselwirkung von CRAC und Ca2+ aktivierten K+ Ionenkanälen

    Derler, I. (PI)

    01.12.2020 → 31.12.2023

    Project: Funded research › FWF - Austrian Science Fund

  • Interplay of CRAC channels with Ca2+ activated K+ channels

    Derler, I. (PI)

    01.06.2020 → 31.05.2024

    Project: Funded research › FWF - Austrian Science Fund

View all 10 projects

Activities

  • 4 Poster presentation

Activities per year

  • Constitutively active Orai TM mutants exhibit altered CRAC characteristics

    Tiffner, A. (Speaker), Höglinger, C. (Speaker), Derler, I. (Speaker), Fahrner, M. (Speaker), Frischauf, I. (Speaker), Schindl, R. (Speaker), Muik, M. (Speaker) & Romanin, C. (Speaker)

    15 Jun 2016

    Activity: Talk or presentation › Poster presentation › unknown

  • A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

    Frischauf, I. (Speaker), Zayats, V. (Speaker), Deix, M. (Speaker), Hochreiter, A. (Speaker), Jardin-Polo, I. (Speaker), Muik, M. (Speaker), Svobodova, B. (Speaker), Pammer, T. (Speaker), Litvinukova, M. (Speaker), Arumbakam, S. (Speaker), Derler, I. (Speaker), Bogeski, I. (Speaker), Romanin, C. (Speaker), Ettrich, R. (Speaker), Schindl, R. (Speaker) & Lackner, B. (Speaker)

    29 Feb 2016

    Activity: Talk or presentation › Poster presentation › unknown

  • NMR investigation and large scale overexpression of isotopically labeled STIM1OASF and Orai1loop2 protein fragments

    Rathner, P. (Speaker), Derler, I. (Speaker), Romanin, C. (Speaker) & Müller, N. (Speaker)

    05 Jul 2015

    Activity: Talk or presentation › Poster presentation › unknown

  • Isoform-specific fine tuning of Orai protein function

    Derler, I. (Speaker)

    08 Jun 2015

    Activity: Talk or presentation › Poster presentation › unknown

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