Synthesis of functionalized porphyrinoid compounds to increase and optimize antiproliferative effects in neuroendocrine tumors

Description

Cationic porphyrins represent an expanding class of compounds, which have several applications in biology, medicine and catalysis and have been studied from the viewpoint of their role as DNA cleavers, G-Quadruplex DNA stabilizers and downregulators of proto-oncogenes (RET, c-Myc, Ras, ERK etc.). Recent studies about the interaction of cationic porphyrins and their derivatives with telomeric DNA have moved porphyrin compounds into the spotlight of an alternative anticancer strategy. The tumoristatic effects of novel completely water soluble symmetric and asymmetric non-metalated and metalated porphyrinoid compounds were evaluated on two cancer types: a) small intestinal neuroendocrine tumor cells (SI-NETs), and b) medullary thyroid carcinoma cells (MTCs). In addition, the intracellular mechanism was elucidated. The tumoristatic effects could be selectively altered on specified neuroendocrine tumors by specific chemical modification of the porphyrinoid compounds.

Period	03 Jul 2012
Event title	Natural Anticaner Drugs
Event type	Conference
Location	Czech RepublicShow on map