Simulation of pharmaceutical solid dispersion during injection moulding by using numerical (CFD) methods

Description

The aim of this poster is to provide insight into the simulation of solid dispersions, consisting of polymer carriers and Active Pharmaceutical Ingredients (APIs). It has been already proven that solid dispersions are able to greatly enhance the bio-availability of APIs [1]. Herein, we have chosen to fabricate drug dosage forms with enhanced solubility by injection moulding technique. The distribution homogeneity of the drug within the polymer matrix must be ensured by the end of the injection moulding process. This is necessary to provide the same drug content and respective activity in each pharmaceutical dosage form. The open source CFD software package OpenFOAM® (Open Field Operation and Manipulation) [2] is used to simulate the API distribution in the melt during processing in the plasticizing unit. The solid dispersion here studied consists of BASF Soluplus® (polymer matrix) and fenofibrate (API). [1] C.A Lipinski, Curr Drug Dis. 2001; 4:17-19 [2] OpenFOAM®, User Guide, Version 2.1.1, 2012

Period	16 Jul 2013
Event title	PPS-29
Event type	Conference
Location	GermanyShow on map