Novel ligands and applications for thermal and photochemical cyclotrimerization reactions with 3d metals

Description

Transition metal-catalyzed [2+2+2] cycloaddition reactions are widely recognized for their versatility and atom efficiency. A notable feature of this reaction is its ability to be mediated or catalyzed by a broad range of transition metals. Among these, first-row late transition metals, such as nickel and cobalt, were among the earliest to show successful examples of catalytic cyclotrimerizations, exhibiting distinct and unique catalytic properties compared to their heavier counterparts. In particular, applying CpCo(I) precatalysts for assembling heterocyclic compounds is a highly versatile tool, working under various conditions and for a steadily extending substrate scope. The field was recently extended to the first application of manganese complexes for photo-catalyzed cyclotrimerization reactions, turning out to be efficient catalysts under irradiation with visible light.
The further development depends on the development of ligands, which modify the reaction space around the catalytically active center. The assembly and implementation of chiral ligands for cobalt-catalyzed cycloaddition reactions is a challenging task, and we will report on our synthetic approaches in this area to efficiently assemble ligand precursors from novel backbones including the efficient construction of symmetrically as well as unsymmetrically Cp rings. The application of the ligands in metal complexes for the synthesis of novel heterocyclic products structures will be exemplified for novel substrates, like shown in Figure 1.

Period	02 Sept 2025
Event title	22nd International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS XXII)
Event type	Conference
Location	Kyoto, JapanShow on map
Degree of Recognition	International