Impedance spectroscopy of a human hepatic 3D cell model in-vitro: A comparative study with differently shaped electrodes

Description

By measuring modulus and phase of either impedance Z or reflection coefficient S11 of differently shaped electrodes which were in defined contact with a biological sample, we showed that electrical parameters may be utilized to assess biological functions on a three-dimensional (3D) in-vitro system. Using the example of a human hepatic 3D cell model we showed that certain frequency domains in the impedance or reflection coefficient spectra may be assigned to specific biological functions, which would possibly enable the investigation of preclinical drug metabolism and toxicity testing in-vitro. Furthermore, we comment on assets and drawbacks of the electrode designs for the use as a measurement probe in biological studies.

Period	06 Sept 2011
Event title	Eurosensors XXV
Event type	Conference
Location	GreeceShow on map