Electrochromic shift calculations explain spectral tuning in light-sensitive proteins

Description

Rhodopsins are biological pigment-proteins found in photoreceptor cells of the retina. Within the framework of a quantum chemical/electrostatic calculation scheme that has recently been successfully applied to reveal the functional states of BLUF photoreceptors [1], we estimated absorption shifts of the retinal cofactor for a series of site-directed mutants. Our calculations accurately reproduce a series of spectroscopic data and eventually the variations of the maximal absorbance in the red- and green-sensitive visual pigments. [1] F. Collette et al., J. Phys. Chem. B 118, 11109 (2014).

Period	20 Mar 2015
Event title	79. Jahrestagung der DPG und DPG-Frühjahrstagung
Event type	Conference
Location	GermanyShow on map