Asymmetrically substituted cationic porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas

Activity: Talk or presentation › Poster presentation › unknown

Description

In this work we presented the synthesis of the fully water soluble cationic porphyrins TMPy3PhenEDTA-P-Cl4, TMPy3PhenIndolprot1P–Cl3 and TMPy3Py-Fluorenyl1P–Cl4 functionalized with EDTA, indole or fluorene moieties. Antiproliferative effects were evaluated in the small intestinal neuroendocrine tumor (SI-NET) cell line KRJ-I [3], the medullary thyroidcarcinoma (MTC) cell line MTC-SK [4] and the human fibroblast cell line HFSAR.
Period15 Jul 2010
Event titleGordon Research Conference - Chemistry & Biology of Tetrapyrroles
Event typeConference
LocationUnited StatesShow on map

Fields of science

  • 107 Other Natural Sciences
  • 204 Chemical Process Engineering
  • 105904 Environmental research
  • 103 Physics, Astronomy
  • 210006 Nanotechnology
  • 104021 Structural chemistry
  • 104016 Photochemistry
  • 106032 Photobiology
  • 301904 Cancer research
  • 301305 Medical chemistry
  • 106002 Biochemistry
  • 211908 Energy research
  • 104003 Inorganic chemistry

JKU Focus areas

  • Nano-, Bio- and Polymer-Systems: From Structure to Function
  • Engineering and Natural Sciences (in general)

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