Identification of CGM Time Delays and Implications for BG Control in T1DM

Florian Reiterer; Philipp Polterauer; Guido Freckmann; Luigi Del Re

doi:10.1007/978-3-319-32703-7_39

Identification of CGM Time Delays and Implications for BG Control in T1DM

Florian Reiterer
, Philipp Polterauer
, Guido Freckmann
, Luigi Del Re

Institut für Maschinelle Intelligenz

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag › Begutachtung

Abstract

Continuous glucose monitoring (CGM) systems are becoming increasingly popular for the management of type 1 diabetes mellitus (T1DM). However, one of the limitations of using CGM information for blood glucose (BG) control is the fact that the CGM sensor measures the glucose not in the blood, but in the interstitial fluid. The current paper shows how a sensor and patient-specific time delay between interstitial glucose (IG) and blood glucose (BG) can be identified from CGM recordings and BG measurements. The resulting time delay values were found to be highly patient-specific and correlated with patient characteristics. Furthermore, it was found that the CGM time delays are a good predictor for the required total daily dose (TDD) of insulin, as well as for the carbohydrate-to-insulin-ratio (CIR). Based on these findings we introduce a method of how insulin therapy in T1DM could possibly be adjusted based on identified CGM time delays.

Originalsprache	Englisch
Titel	IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016
Herausgeber*innen	Efthyvoulos Kyriacou, Stelios Christofides, Constantinos S. Pattichis
Verlag	Springer
Seiten	190-195
Seitenumfang	6
Band	57
ISBN (Print)	978-3-319-32701-3
DOIs	https://doi.org/10.1007/978-3-319-32703-7_39
Publikationsstatus	Veröffentlicht - Apr. 2016

Publikationsreihe

Name	IFMBE Proceedings
Band	57
ISSN (Print)	1680-0737

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Wissenschaftszweige

206002 Elektromedizinische Technik
207109 Schadstoffemission
202 Elektrotechnik, Elektronik, Informationstechnik
202027 Mechatronik
202034 Regelungstechnik
203027 Verbrennungskraftmaschinen
206001 Biomedizinische Technik

JKU-Schwerpunkte

Mechatronics and Information Processing

Zugriff auf Dokument

10.1007/978-3-319-32703-7_39

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

Dieses zitieren

Reiterer, F., Polterauer, P., Freckmann, G., & Del Re, L. (2016). Identification of CGM Time Delays and Implications for BG Control in T1DM. in E. Kyriacou, S. Christofides, & C. S. Pattichis (Hrsg.), IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016 (Band 57, S. 190-195). (IFMBE Proceedings; Band 57). Springer. https://doi.org/10.1007/978-3-319-32703-7_39

Reiterer, Florian ; Polterauer, Philipp ; Freckmann, Guido et al. / Identification of CGM Time Delays and Implications for BG Control in T1DM. IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Hrsg. / Efthyvoulos Kyriacou ; Stelios Christofides ; Constantinos S. Pattichis. Band 57 Springer, 2016. S. 190-195 (IFMBE Proceedings).

@inproceedings{f61a474d2de845909838c71e64c7cd80,

title = "Identification of CGM Time Delays and Implications for BG Control in T1DM",

abstract = "Continuous glucose monitoring (CGM) systems are becoming increasingly popular for the management of type 1 diabetes mellitus (T1DM). However, one of the limitations of using CGM information for blood glucose (BG) control is the fact that the CGM sensor measures the glucose not in the blood, but in the interstitial fluid. The current paper shows how a sensor and patient-specific time delay between interstitial glucose (IG) and blood glucose (BG) can be identified from CGM recordings and BG measurements. The resulting time delay values were found to be highly patient-specific and correlated with patient characteristics. Furthermore, it was found that the CGM time delays are a good predictor for the required total daily dose (TDD) of insulin, as well as for the carbohydrate-to-insulin-ratio (CIR). Based on these findings we introduce a method of how insulin therapy in T1DM could possibly be adjusted based on identified CGM time delays.",

author = "Florian Reiterer and Philipp Polterauer and Guido Freckmann and \{Del Re\}, Luigi",

year = "2016",

month = apr,

doi = "10.1007/978-3-319-32703-7\_39",

language = "English",

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booktitle = "IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016",

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Reiterer, F, Polterauer, P, Freckmann, G & Del Re, L 2016, Identification of CGM Time Delays and Implications for BG Control in T1DM. in E Kyriacou, S Christofides & CS Pattichis (Hrsg.), IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Bd. 57, IFMBE Proceedings, Bd. 57, Springer, S. 190-195. https://doi.org/10.1007/978-3-319-32703-7_39

Identification of CGM Time Delays and Implications for BG Control in T1DM. / Reiterer, Florian; Polterauer, Philipp; Freckmann, Guido et al.
IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Hrsg. / Efthyvoulos Kyriacou; Stelios Christofides; Constantinos S. Pattichis. Band 57 Springer, 2016. S. 190-195 (IFMBE Proceedings; Band 57).

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag › Begutachtung

TY - GEN

T1 - Identification of CGM Time Delays and Implications for BG Control in T1DM

AU - Reiterer, Florian

AU - Polterauer, Philipp

AU - Freckmann, Guido

AU - Del Re, Luigi

PY - 2016/4

Y1 - 2016/4

N2 - Continuous glucose monitoring (CGM) systems are becoming increasingly popular for the management of type 1 diabetes mellitus (T1DM). However, one of the limitations of using CGM information for blood glucose (BG) control is the fact that the CGM sensor measures the glucose not in the blood, but in the interstitial fluid. The current paper shows how a sensor and patient-specific time delay between interstitial glucose (IG) and blood glucose (BG) can be identified from CGM recordings and BG measurements. The resulting time delay values were found to be highly patient-specific and correlated with patient characteristics. Furthermore, it was found that the CGM time delays are a good predictor for the required total daily dose (TDD) of insulin, as well as for the carbohydrate-to-insulin-ratio (CIR). Based on these findings we introduce a method of how insulin therapy in T1DM could possibly be adjusted based on identified CGM time delays.

AB - Continuous glucose monitoring (CGM) systems are becoming increasingly popular for the management of type 1 diabetes mellitus (T1DM). However, one of the limitations of using CGM information for blood glucose (BG) control is the fact that the CGM sensor measures the glucose not in the blood, but in the interstitial fluid. The current paper shows how a sensor and patient-specific time delay between interstitial glucose (IG) and blood glucose (BG) can be identified from CGM recordings and BG measurements. The resulting time delay values were found to be highly patient-specific and correlated with patient characteristics. Furthermore, it was found that the CGM time delays are a good predictor for the required total daily dose (TDD) of insulin, as well as for the carbohydrate-to-insulin-ratio (CIR). Based on these findings we introduce a method of how insulin therapy in T1DM could possibly be adjusted based on identified CGM time delays.

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Reiterer F, Polterauer P, Freckmann G, Del Re L. Identification of CGM Time Delays and Implications for BG Control in T1DM. in Kyriacou E, Christofides S, Pattichis CS, Hrsg., IFMBE Proceedings, XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Band 57. Springer. 2016. S. 190-195. (IFMBE Proceedings). doi: 10.1007/978-3-319-32703-7_39