Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration

Sandra Rothemund; Tamara Aigner; Aitziber Iturmendi; Maria Rigau; Branislav Husár; Florian Hildner; Eleni Oberbauer; Martina Prambauer; Gbenga Olawale; Reinhard Forstner; Robert Liska; Klaus Schröder; Oliver Brüggemann; Ian Teasdale

doi:10.1002/mabi.201400390

Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration

Sandra Rothemund
, Tamara Aigner
, Aitziber Iturmendi
, Maria Rigau
, Branislav Husár
, Florian Hildner
, Eleni Oberbauer
, Martina Prambauer
, Gbenga Olawale
, Reinhard Forstner
, Robert Liska
, Klaus Schröder
, Oliver Brüggemann
, Ian Teasdale

Institut für Chemie der Polymere

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.

Originalsprache	Englisch
Seiten (von - bis)	351-363
Seitenumfang	13
Fachzeitschrift	Macromolecular Bioscience
Volume	15
Ausgabenummer	3
DOIs	https://doi.org/10.1002/mabi.201400390
Publikationsstatus	Veröffentlicht - März 2015

Wissenschaftszweige

304007 Tissue Engineering
204002 Chemische Reaktionstechnik
210004 Nanomaterialien
104 Chemie
104002 Analytische Chemie
104011 Materialchemie
104014 Oberflächenchemie
104016 Photochemie
104018 Polymerchemie
104008 Katalyse
104010 Makromolekulare Chemie
104015 Organische Chemie
104019 Polymerwissenschaften
106002 Biochemie
107002 Bionik
301305 Medizinische Chemie
301207 Pharmazeutische Chemie
301904 Krebsforschung
302009 Chemotherapie

JKU-Schwerpunkte

Nano-, Bio- and Polymer-Systems: From Structure to Function
TNF Allgemein

Zugriff auf Dokument

10.1002/mabi.201400390

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Rothemund, S., Aigner, T., Iturmendi, A., Rigau, M., Husár, B., Hildner, F., Oberbauer, E., Prambauer, M., Olawale, G., Forstner, R., Liska, R., Schröder, K., Brüggemann, O., & Teasdale, I. (2015). Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration. Macromolecular Bioscience, 15(3), 351-363. https://doi.org/10.1002/mabi.201400390

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abstract = "Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.",

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Rothemund, S, Aigner, T, Iturmendi, A, Rigau, M, Husár, B, Hildner, F, Oberbauer, E, Prambauer, M, Olawale, G, Forstner, R, Liska, R, Schröder, K, Brüggemann, O & Teasdale, I 2015, 'Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration', Macromolecular Bioscience, Jg. 15, Nr. 3, S. 351-363. https://doi.org/10.1002/mabi.201400390

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AU - Rothemund, Sandra

AU - Aigner, Tamara

AU - Iturmendi, Aitziber

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AU - Husár, Branislav

AU - Hildner, Florian

AU - Oberbauer, Eleni

AU - Prambauer, Martina

AU - Olawale, Gbenga

AU - Forstner, Reinhard

AU - Liska, Robert

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AU - Brüggemann, Oliver

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